AUTHOR=Wang Yujie , Gao Peng , Hao Zhibin , Chen Ling , Li Xiaoxiao , Jiao Yuan , Liu Jingyu , Li Jie , Zhang Yingyi , Peng Xiaobo , Ning Beifang , Zhan Xianbao TITLE=The effect of neoadjuvant chemotherapy on the tumor immune microenvironment in gastrointestinal tumors JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1054598 DOI=10.3389/fonc.2022.1054598 ISSN=2234-943X ABSTRACT=

In recent years, numerous studies have demonstrated that the tumor immune microenvironment (TIME) is capable of regulating the growth of tumors, and tumor-infiltrating immune cells in the TIME can affect the prognosis and treatment responses of patients. Consequently, therapies targeting these immune cells have emerged as important antitumor treatments. As a crucial componet of the perioperative treatment of malignant tumors, neoadjuvant chemotherapy (NACT) can improve the surgical resection rate and prognosis of patients and is a suitable clinical model to evaluate the effect of chemotherapy on the TIME. To provide a rationale for developing valid combinational therapies, this review summarizes the impact of NACT on the TIME, the relationship between tumor-infiltrating immune cells and treatment responses of patients, and the prognostic value of these infiltrating immune cells.