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Shaomin Shi1,2,3,4†
Chongyang Li2,3†
Yanli Zhang1
Chaowei Deng2,3
Wei Liu1
Juan Du1
Qian Li1
Yacong Ji1
Leiyang Guo1
Lichao Liu1
Huanrong Hu1
Yaling Liu1*
Hongjuan Cui2,3*- 1Department of Dermatology, Third Hospital of Hebei Medical University, Shijiazhuang, China
- 2State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China
- 3Cancer Center, Medical Research Institute, Southwest University, Chongqing, China
- 4Department of Dermatology, Fifth Hospital of Shijiazhuang, Shijiazhuang, China
A corrigendum on
Dihydrocapsaicin inhibits cell proliferation and metastasis in melanoma via down-regulating β-catenin pathway
by Shi S, Li C, Zhang Y, Deng C, Liu W, Du J, Li Q, Ji Y, Guo L, Liu L, Hu H, Liu Y and Cui H (2021) doi: 10.3389/fonc.2021.648052
In the original article, there were mistakes in Figures 5 and 6 as published. We found that the migration transwell assay image of “A375-Vector+DMSO” in Figure 5A, invasion transwell assay images of “A375-Vector+DHC”, “MV3-β-catenin+DHC” in Figure 5B, and soft agar assay image of “A375-Vector+DHC” in Figure 6A were inadvertently presented with incorrect pictures. The corrected Figures 5 and its caption “Overexpression of β-catenin retrieves DHC-induced cell migration and invasion inhibition. (A, B) Migration and invasion transwell assays were performed in β-catenin/vector overexpressed A375 and MV3 cells treated with 100 μM DHC. Scale bar, 100 μm. (C, D) The protein expression of β-catenin, MMP2 and MMP7 in β-catenin/vector overexpressed A375 and MV3 cells treated with 100 μM DHC for 48 h. (E, F) The mRNA expression of MMP2 and MMP7 in β-catenin/vector overexpressed A375 and MV3 cells treated with 100 μM DHC for 48 h. *P < 0.05; **P < 0.01; ***P < 0.001” and Figure 6 and its caption “Overexpression of β-catenin retrieves DHC-induced inhibition of tumor growth and pulmonary metastasis of melanoma cells. (A) Colonies generated by β-catenin/vector overexpressed A375 and MV3 cells after treatment with 100 μM DHC for 3 weeks. Scale bar, 1 mm. (B) Tumor volume of β-catenin/vector overexpressed A375 xenograft tumors in mice after treatment with DHC (20 mg/kg/day for 28 days) and DMSO. (C, D) The tumors in mice were excised and weighed. (E) IHC of β-catenin and Ki67 in the xenograft tumors. Scale bar, 100 μm. (F) H&E staining of the lungs from β-catenin/vector overexpressed A375 metastasis mice model after treatment with DHC (20 mg/kg/day for 45 days) and DMSO. *P < 0.05; **P < 0.01; ***P < 0.001” appear below.
FIGURE 5
Figure 5 Overexpression of β-catenin retrieves DHC-induced cell migration and invasion inhibition. (A, B) Migration and invasion transwell assays were performed in β-catenin/vector overexpressed A375 and MV3 cells treated with 100 μM DHC. Scale bar, 100 μm. (C, D) The protein expression of β-catenin, MMP2 and MMP7 in β-catenin/vector overexpressed A375 and MV3 cells treated with 100 μM DHC for 48 h. (E, F) The mRNA expression of MMP2 and MMP7 in β-catenin/vector overexpressed A375 and MV3 cells treated with 100 μM DHC for 48 h. *P < 0.05; **P < 0.01; ***P < 0.001.
FIGURE 6
Figure 6 Overexpression of β-catenin retrieves DHC-induced inhibition of tumor growth and pulmonary metastasis of melanoma cells. (A) Colonies generated by β-catenin/vector overexpressed A375 and MV3 cells after treatment with 100 μM DHC for 3 weeks. Scale bar, 1 mm. (B) Tumor volume of β-catenin/vector overexpressed A375 xenograft tumors in mice after treatment with DHC (20 mg/kg/day for 28 days) and DMSO. (C, D) The tumors in mice were excised and weighed. (E) IHC of β-catenin and Ki67 in the xenograft tumors. Scale bar, 100 μm. (F) H&E staining of the lungs from β-catenin/vector overexpressed A375 metastasis mice model after treatment with DHC (20 mg/kg/day for 45 days) and DMSO. *P < 0.05; **P < 0.01; ***P < 0.001.
The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Keywords: dihydrocapsaicin, melanoma, cell proliferation, metastasis, β-catenin, ubiquitination
Citation: Shi S, Li C, Zhang Y, Deng C, Liu W, Du J, Li Q, Ji Y, Guo L, Liu L, Hu H, Liu Y and Cui H (2022) Corrigendum: Dihydrocapsaicin inhibits cell proliferation and metastasis in melanoma via down-regulating β-catenin pathway. Front. Oncol. 12:1052365. doi: 10.3389/fonc.2022.1052365
Received: 23 September 2022; Accepted: 28 September 2022;
Published: 11 October 2022.
Edited and Reviewed by:
Qingxin Mu, University of Washington, United StatesCopyright © 2022 Shi, Li, Zhang, Deng, Liu, Du, Li, Ji, Guo, Liu, Hu, Liu and Cui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Yaling Liu, eXpsaW5nX2xpdTEyMTRAMTI2LmNvbQ==; Hongjuan Cui, aGN1aUBzd3UuZWR1LmNu
†These authors have contributed equally to this work