AUTHOR=Zhang Lu , Xiang Junyu , Zhang Fang , Liu Limei , Hu Chongling 

TITLE=MSCs can be a double-edged sword in tumorigenesis

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1047907

DOI=10.3389/fonc.2022.1047907

ISSN=2234-943X

ABSTRACT=<p>Mesenchymal stem cells (MSCs) have been used to treat various diseases including Alzheimer’s disease and cancer. In particular, the immunomodulatory function of MSCs plays a major role in cancer therapy using stem cells. However, MSCs exert promotive and inhibitory effects on cancer. The immunomodulatory effects of MSCs in the tumor microenvironment (TME) are ambiguous, which is the primary reason for the different outcomes of MSCs therapies for tumors. This review discusses the use of MSCs in cancer immunotherapy and their immunomodulatory mechanisms in cancers.</p>