Highly Invasive Fluorescent/Bioluminescent Patient-Derived Orthotopic Model of Glioblastoma in Mice
- 1Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, Nizhny Novgorod, Russia
- 2R&D Department, Becker&Hickl GmbH, Berlin, Germany
- 3Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia
- 4Laboratory of Molecular Oncology, Federal Research and Clinical Center of Physical and Chemical Medicine, Moscow, Russia
- 5Biomedical Research Center, Federal Research and Clinical Center, Federal Medical and Biological Agency, Moscow, Russia
- 6Laboratory of Molecular Mechanisms of Regeneration and Aging, Engelhardt Institute of Molecular Biology, Moscow, Russia
- 7Department of Molecular Immunology, Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia
A corrigendum on
Highly invasive fluorescent/bioluminescent patient-derived orthotopic model of glioblastoma in mice
by Yuzhakova D, Kiseleva E, Shirmanova M, Shcheslavskiy V, Sachkova D, Snopova L, Bederina E, Lukina M, Dudenkova V, Yusubalieva G, Belovezhets T, Matvienko D and Baklaushev V (2022). 12:897839. doi: 10.3389/fonc.2022.897839
In the published article, there was an error in the order for Figure 7 and Figure 8 as published. The images from Figure 7 and Figure 8 were interchanged, while the Figure legends were in the right places. The corrected Figure 7 and Figure 8 appear below.
Figure 7 Macro-FLIM of human GBM xenografts and normal brain. (A) Representative autofluorescence time-resolved images of GBM7-Luc2-mKate2 xenografts, U87 MG xenograft and normal mouse brain without tumor. Enlarged regions with a tumor are indicated by the black squares on the lower-magnification panel. Corresponding H&E stained section is presented under each enlarged region. (B) Quantification of the mean fluorescence lifetime tm in NAD(P)H spectral channel in (1) dual-labeled human GBM xenografts and (2) U87 MG xenografts and normal brain. Scatter dot plot displays the measurements for individual animals (dots) and the mean and SEM (horizontal lines). WM is a white matter.
Figure 8 Wide-field OCT color-coded maps of the mouse brain with GBM7-Luc2-mKate2 tumor (A, B) and corresponding histology (C). Color-coded maps based on two optical coefficients calculation: attenuation in co-channel (Attco-) (A) and in cross-channel (Attcross-) (B). Perifocal areas of high cancer density are marked with arrows (see enlarged fragments). T, tumor; C, cortex; WM, white matter.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.
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Keywords: glioblastoma (GBM), primary cell line, patient-derived xenograft (PDX), fluorescence imaging, FLIM (fluorescence lifetime imaging microscopy)
Citation: Yuzhakova D, Kiseleva E, Shirmanova M, Shcheslavskiy V, Sachkova D, Snopova L, Bederina E, Lukina M, Dudenkova V, Yusubalieva G, Belovezhets T, Matvienko D and Baklaushev V (2022) Corrigendum: Highly invasive fluorescent/bioluminescent patient-derived orthotopic model of glioblastoma in mice. Front. Oncol. 12:1040637. doi: 10.3389/fonc.2022.1040637
Received: 09 September 2022; Accepted: 15 September 2022;
Published: 29 September 2022.
Edited and Reviewed by:
Ellen Ackerstaff, Memorial Sloan Kettering Cancer Center, United StatesCopyright © 2022 Yuzhakova, Kiseleva, Shirmanova, Shcheslavskiy, Sachkova, Snopova, Bederina, Lukina, Dudenkova, Yusubalieva, Belovezhets, Matvienko and Baklaushev. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Diana Yuzhakova, eXV6aGFrb3ZhLWRpYW5hQG1haWwucnU=; Vladislav Shcheslavskiy, dmlzQGJlY2tlci1oaWNrbC5kZQ==
†These authors have contributed equally to this work