AUTHOR=Li Yunjin , Cao Yi , Wu Xiaoying , Liu Ruijie , Wang Kuansong 

TITLE=HER-2-positive primary neuroendocrine neoplasms of the breast with signet ring feature: A case report and review of literature

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1029007

DOI=10.3389/fonc.2022.1029007

ISSN=2234-943X

ABSTRACT= Primary neuroendocrine neoplasm of the breast (BNEN) is an uncommon breast neoplasm, and in most cases, it presents as hormone receptors positive and HER-2 negative. Moreover, in neuroendocrine neoplasms (NENs), the signet ring feature is a rare morphological subtype and only a few cases have been reported. Here, we report the case of a primary breast neuroendocrine neoplasm with an unusual signet ring cell appearance in this paper. The documentation of this case, combined with a review of the literature, may add to existing knowledge about the outcome and management of this rare tumor.