AUTHOR=Poumeaud François , Fontanier Anna , Dion Jérémie , Mathevet Quentin , Cointault Olivier , Uro-Coste Emmanuelle , Marty Céline , Dalenc Florence , Girardie Pierre , Rataboul Anaïs TITLE=Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1026434 DOI=10.3389/fonc.2022.1026434 ISSN=2234-943X ABSTRACT=

We report the fourth described case of severe toxic rhabdomyolysis occurring in an 81-year-old woman caused by the concomitant administration of palbociclib taken at the usual dosage (125 mg per day) and simvastatin. To the best of our knowledge, this is the first reported case successfully treated by plasma exchanges, with complete functional recovery within two months. The severity of this case justifies further consideration of pharmacokinetic interactions between palbociclib or other CDK-4-6 inhibitors and statins, which potentially increase the risk of an adverse event.