AUTHOR=Tian Kun , Liu Yating , Zhu Haiying , Wang Tao , Chen Tianxing , Pei Xiaxia , Song Feixue 

TITLE=A case report of primary cardiac angiosarcoma with DNMT3A gene mutation

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1018741

DOI=10.3389/fonc.2022.1018741

ISSN=2234-943X

ABSTRACT=<p>Cardiac angiosarcoma is a rare disease with a high mortality rate despite its low incidence. Surgery is currently the mainstay treatment strategy for patients with this condition. Herein, we describe a case of primary cardiac angiosarcoma, including symptoms, examination findings, treatment strategy and prognosis. In 2020, the patient was admitted to our hospital, and Next-Generation Sequencing (NGS) revealed a mutation in the <italic>DNMT3A</italic> gene. Generally, <italic>DNMT3A</italic> mutations are most commonly seen in atherosclerosis and myeloid leukemia. To our knowledge, this is the first reported case of primary cardiac angiosarcoma with <italic>DNMT3A</italic> gene mutation.</p>