AUTHOR=Wang Shaotai , Hu Min , Song Dongsheng , Tang Linjun , Jiang Huan 

TITLE=Research progress on the role and mechanism of miR-671 in bone metabolism and bone-related diseases

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1018308

DOI=10.3389/fonc.2022.1018308

ISSN=2234-943X

ABSTRACT=<p>Bone metabolism consists of bone formation and resorption and maintains a dynamic balance <italic>in vivo</italic>. When bone homeostasis is broken, it can manifest as osteoarthritis (OA), rheumatoid arthritis (RA), osteosarcoma (OS), etc. MiR-671, an important class of non-coding nucleotide sequences <italic>in vivo</italic>, is regulated by lncRNA and regulates bone metabolism balance by regulating downstream target proteins and activating various signaling pathways. Based on the structure and primary function of miR-671, this paper summarizes the effect and mechanism of miR-671 in bone-related inflammation and cancer diseases, and prospects the application possibility of miR-671, providing reference information for targeted therapy of bone-related disorders.</p>