AUTHOR=Wu Junchao , Yu Sijie , Wang Yalan , Zhu Jie , Zhang Zhenhua 

TITLE=New insights into the role of ribonuclease P protein subunit p30 from tumor to internal reference

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1018279

DOI=10.3389/fonc.2022.1018279

ISSN=2234-943X

ABSTRACT=<p>Ribonuclease P protein subunit p30 (<italic>RPP30</italic>) is a highly conserved housekeeping gene that exists in many species and tissues throughout the three life kingdoms (archaea, bacteria, and eukaryotes). <italic>RPP30</italic> is closely related to a few types of tumors in human diseases but has a very stable transcription level in most cases. Based on this feature, increasing number of studies have used <italic>RPP30</italic> as an internal reference gene. Here, the structure and basic functions of <italic>RPP30</italic> are summarized and the likely relationship between <italic>RPP30</italic> and various diseases in plants and human is outlined. Finally, the current application of <italic>RPP30</italic> as an internal reference gene and its advantages over traditional internal reference genes are reviewed. <italic>RPP30</italic> characteristics suggest that it has a good prospect of being selected as an internal reference; more work is needed to develop this research avenue.</p>