AUTHOR=Sang Lei , Wang Xingshun , Bai Weiyu , Shen Junling , Zeng Yong , Sun Jianwei 

TITLE=The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1011230

DOI=10.3389/fonc.2022.1011230

ISSN=2234-943X

ABSTRACT=<p>Hepatocyte Nuclear Factor 4 Alpha (HNF4α) is a master transcription factor mainly expressed in the liver, kidney, intestine and endocrine pancreas. It regulates multiple target genes involved in embryonic development and metabolism. HNF4α-related diseases include non-alcoholic fatty liver disease (NAFLD), obesity, hypertension, hyperlipidemia, metabolic syndrome and diabetes mellitus. Recently, HNF4α has been emerging as a key player in a variety of cancers. In this review, we summarized the role and mechanism of HNF4α in different types of cancers, especially in liver and colorectal cancer, aiming to provide additional guidance for intervention of these diseases.</p>