AUTHOR=Xue Chi , Du Yuwei , Li Yuegang , Xu Huimian , Zhu Zhi 

TITLE=Tumor budding as a predictor for prognosis and therapeutic response in gastric cancer: A mini review

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1003959

DOI=10.3389/fonc.2022.1003959

ISSN=2234-943X

ABSTRACT=<p>In recent years, the role of tumor budding in gastric cancer has received increased attention across a number of disciplines. Several studies have found associations between tumor budding and the prediction of lymph node metastasis in early gastric cancer, prognosis of advanced gastric cancer, predictors of therapeutic response to immune checkpoint inhibitors, such as microsatellite instability (MSI), and therapeutic targets of molecular targeted therapy, such as human epidermal growth factor receptor 2 (HER-2). Therefore, tumor budding is a major element in the formulation of risk stratification and precision medicine strategies for patients with gastric cancer.</p>