AUTHOR=da Silva Filipa Ferreira , Barata Rita , Rolim Inês , Carvalheiro Catarina , Gil Nuno , Pantarotto Marcos 

TITLE=Case report: Using DNA short tandem repeats to confirm nongestational origin of pulmonary choriocarcinoma

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1001627

DOI=10.3389/fonc.2022.1001627

ISSN=2234-943X

ABSTRACT=<p>Gestational trophoblastic neoplasias (GTN) are malignant neoplasms that occur in pregnant or recently pregnant women. Choriocarcinoma (CCA) is a highly aggressive and rare GTN, and cases outside the female genital tract are commonly seen as secondary manifestations of gynecologic disease. In this paper, we describe the case of a 40 years-old female patient with a primary pulmonary CCA who was surgically treated and for whom the confirmation of the primary origin of the tumor was possible using a DNA short tandem repeat genotyping. Distinction between gestational and non-gestational trophoblastic neoplasia is crucial as they require different therapeutic approach and have different prognoses.</p>