AUTHOR=Li Difeng , Zhang Xin , Jiang Lili 

TITLE=Molecular mechanism and potential therapeutic targets of liver metastasis from gastric cancer

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1000807

DOI=10.3389/fonc.2022.1000807

ISSN=2234-943X

ABSTRACT=Gastric cancer (GC) is characterized by high invasion and poor prognosis. The occurrence of liver metastasis seriously affects the prognosis of advanced GC. In recent years, great progress has been made in liver metastasis from GC. The abnormal expression of related genes leads to the occurrence of liver metastasis from GC through metastasis cascades. The changes in liver microenvironment provide a pre-metastasis condition for GC cells to colonize and grow. The development of several potential therapeutic targets may provide new therapeutic strategies for its treatment. Therefore, we review the regulatory mechanism of abnormal genes mediated liver metastasis, the effect of liver resident cells on liver metastasis, and potential therapeutic targets, hoping to provide a novel therapeutic option to improve the life quality and prognosis of patients with liver metastasis from GC.