AUTHOR=Tang Enyu , Liu Siyang , Zhang Zhiming , Zhang Rixin , Huang Dejing , Gao Tong , Zhang Tianze , Xu Guangquan 

TITLE=Therapeutic Potential of Glutamine Pathway in Lung Cancer

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.835141

DOI=10.3389/fonc.2021.835141

ISSN=2234-943X

ABSTRACT=<p>Cancer cells tend to obtain the substances needed for their development depending on altering metabolic characteristics. Among the reorganized metabolic pathways, Glutamine pathway, reprogrammed to be involved in the physiological process including energy supply, biosynthesis and redox homeostasis, occupies an irreplaceable role in tumor cells and has become a hot topic in recent years. Lung cancer currently maintains a high morbidity and mortality rate among all types of tumors and has been a health challenge that researchers have longed to overcome. Therefore, this study aimed to clarify the essential role of glutamine pathway played in the metabolism of lung cancer and its potential therapeutic value in the interventions of lung cancer.</p>