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Wendong Yang1Zhongwei Li1,2Rong Qin1,2Xiaorui Wang3
Huihui An1,2Yule Wang4,5Yan Zhu4,5
Yantao Liu1,2Shijiao Cai1
Shuang Chen2
Tao Sun1,2*
Jing Meng1,2*Cheng Yang1,2*- 1State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China
- 2Tianjin Key Laboratory of Early Druggability Evaluation of Innovative Drugs and Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, China
- 3College of Life Sciences, Nankai University, Tianjin, China
- 4Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
- 5Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin, China
A Corrigendum on:
YY1 Promotes Endothelial Cell-Dependent Tumor Angiogenesis in Hepatocellular Carcinoma by Transcriptionally Activating VEGFA
By Yang W, Li Z, Qin R, Wang X, An H, Wang Y, Zhu Y, Liu Y, Cai S, Chen S, Sun T, Meng J and Yang C (2019) Front. Oncol. 9:1187. doi: 10.3389/fonc.2019.01187
In the original article, there was a mistake in Figure 4B as published. The HAEC tubes formation following an incubation with supernatants collected from the YY1 overexpression cells was placed mistakenly using the same image of HUVECs tubes with same treatment in Figure 4B. The mistake was inadvertently introduced in the preparation of revision manuscript. The corrected Figure 4 appears below.
FIGURE 4
Figure 4 YY1 stimulated HCC cell culture media accelerated endothelial cells neovascularization. (A) HUVECs and HAECs (red) and HepG2 cells (green) co-cultured in a 1:2 ratio and formed three-dimensional spheroids. Images were taken with a laser scanning confocal microscope, scale bar = 50 μm. (B) Representative image (left) of the formation of HUVECs and HAECs tubes following an incubation with supernatants collected from the indicated cells. Tube formation quantification were analyzed (right). Scale bar = 50 μm. (C) HUVECs and HAECs migration were detected after an incubation with supernatants collected from the indicated cells. (D) HUVECs and HAECs invasion were detected following an incubation with supernatants collected from the indicated cells. Scale bar = 20 μm. (E) WB analyzed pVEGFR2 expression in HUVECs and HAECs treated with conditioned media. (F) Immunofluorescence of pVEGFR2 expression in HUVECs and HAECs treated with conditioned media. Scale bar = 10 μm. *P < 0.05, **P < 0.01.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Keywords: YY1, angiogenesis, vascular endothelial growth factor A, transcription activation, hepatocellular carcinoma
Citation: Yang W, Li Z, Qin R, Wang X, An H, Wang Y, Zhu Y, Liu Y, Cai S, Chen S, Sun T, Meng J and Yang C (2022) Corrigendum: YY1 Promotes Endothelial Cell-Dependent Tumor Angiogenesis in Hepatocellular Carcinoma by Transcriptionally Activating VEGFA. Front. Oncol. 11:828861. doi: 10.3389/fonc.2021.828861
Received: 06 December 2021; Accepted: 09 December 2021;
Published: 13 January 2022.
Edited and reviewed by:
Laurence A. Marchat, Instituto Politécnico Nacional, MexicoCopyright © 2022 Yang, Li, Qin, Wang, An, Wang, Zhu, Liu, Cai, Chen, Sun, Meng and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Tao Sun, dGFvLnN1bkBuYW5rYWkuZWR1LmNu; Jing Meng, bWVuZ2ppbmcwMTAxQDE2My5jb20=; Cheng Yang, Y2hlbmcueWFuZ0BuYW5rYWkuZWR1LmNu