Skip to main content

CASE REPORT article

Front. Oncol., 22 December 2021
Sec. Radiation Oncology
This article is part of the Research Topic HDR brachytherapy in prostate cancer View all 4 articles

Case Report: Role of an Iodinated Rectal Hydrogel Spacer, SpaceOAR Vue™, in the Context of Low-Dose-Rate Prostate Brachytherapy, for Enhanced Post-Operative Contouring to Aid in Accurate Implant Evaluation and Dosimetry

Andrew GrossAndrew GrossJiankui YuanJiankui YuanDaniel SprattDaniel SprattElisha Fredman*Elisha Fredman*
  • Department of Radiation Oncology, Seidman Cancer Center, University Hospitals Cleveland Medical Center, Cleveland, OH, United States

We present a case series of 13 consecutive patients with prostate cancer treated with low-dose-rate (LDR) brachytherapy, utilizing SpaceOAR Vue™, the recent iodinated iteration of the SpaceOAR™ hydrogel rectal spacer. Low- and favorable intermediate-risk patients receiving monotherapy and unfavorable intermediate- and high-risk patients undergoing a brachytherapy boost were included. Permanent brachytherapy can result in subacute and late rectal toxicity, and precise contouring of the anterior rectal wall and posterior aspect of the prostate is essential for accurate dosimetry to confirm a safe implant. Clearly visible on non-contrast CT imaging, SpaceOAR Vue™ can substantially aid in post-implant contouring and analysis. Not previously described in the literature in the context of LDR brachytherapy, we demonstrate the added clinical benefit of placing a well-visualized rectal spacer.

Background

Low-dose-rate (LDR) brachytherapy with permanent implantation of radioactive seeds is a highly effective method of delivering curative radiation therapy for prostate cancer (1, 2). As monotherapy for low- and favorable intermediate-risk disease and in combination with external beam radiation (EBRT) for unfavorable intermediate- and high-risk disease, LDR brachytherapy yields biochemical progression-free survival rates of approximately 96 and 89–94%, respectively (35). In fact, compared to all other radiation therapy modalities, LDR brachytherapy allows for the highest possible dose to be delivered to the prostate gland (6). It is this very feature, however, that makes limiting exposure to surrounding critical structures, as assessed by precise contouring and dosimetric calculation, particularly important.

Anatomically, the rectum is situated immediately posterior to the posterior aspect of the prostate and is typically the dose-limiting adjacent tissue. While this structure can tolerate a certain degree of radiation exposure, an excessive dose to a given point or a volumetric region can result in subacute and late side effects that range from bothersome to potentially life-threatening (710). Therefore, when calculating radiation dose to the anterior rectal wall as part of the post-operative implant evaluation, accurate demarcation and contouring of the rectum and its position relative to the posterior aspect of the prostate is essential (11). This is especially important in LDR brachytherapy due to the exceptionally high radiation doses delivered and the permanent nature of the seeds, yet it is uniquely challenging due to a degree of local bleeding and edema caused by the transperineal brachytherapy procedure and CT artifact from the metallic seeds or other high-density materials.

One method to decrease radiation dose to the rectum, to reduce the risk of rectal toxicity, is transperineal injection of a biomaterial into the potential fat space between Denonvilliers’ fascia and the anterior rectal wall (12). Polyethylene glycol (PEG)-based absorbable hydrogel SpaceOAR™ (Boston Scientific Corporation) reduces both objective high-dose exposure to the rectum and patient-reported rectal toxicity in the setting of EBRT and stereotactic body radiotherapy (1214). This FDA-approved rectal spacer is now widely used when delivering high-dose prostate radiation therapy.

PEG hydrogel application in the context of LDR brachytherapy presents a unique challenge for post-operative dosimetry (15). While hyperintense on T2-weighted MRI, the hydrogel appears isodense on CT, and even though external radiation is frequently planned utilizing MRI fusion, post-implant dosimetry is most often calculated on CT imaging alone. Following the brachytherapy procedure, the presence of low/moderate-grade edema and bleeding proximal and posterior to the prostate can make it difficult to identify the precise location of the hydrogel and the anterior rectal wall, making proper contouring and accurate post-implant dosimetry a challenge (Figure 1A). Furthermore, the streak artifact caused by the brachytherapy seeds as well as by other high-density implanted materials, such as a metallic hip replacement, can obscure the boundaries of the rectal wall.

FIGURE 1
www.frontiersin.org

Figure 1 Day 0 non-contrast CT scan for postoperative dosimetry following low-dose-rate brachytherapy with placement of a standard SpaceOAR™ (A) and SpaceOAR Vue™ (B).

More recently, a novel iteration of the SpaceOAR™ product was developed, SpaceOAR Vue™, an iodinated cross-linked PEG hydrogel, making the similarly resorbable hydrogel radiopaque easily seen on non-contrast CT. The properties of the standard SpaceOAR™, namely, transformation from liquid components to a solid gel-like material in fractions of a second, stability over at least 3 months, and being hydrolyzed and renally cleared at approximately 6 months, are unchanged in the iodinated version (16). The primary function of the SpaceOAR Vue™, namely, stable and consistent peri-rectal spacing, has recently been objectively compared to that of its non-iodinated predecessor. In a rigorous longitudinal comparison analysis, it was found that, despite a moderately overall smaller average delineated volume, SpaceOAR Vue™ provided comparable relative prostate–rectal separation, appropriate positioning, stability over a course of EBRT, and dosimetric consistency without significant changes in plan quality or robustness relative to SpaceOAR™ (17).

Specifically, its distinct visibility on non-contrast CT potentially makes it particularly beneficial as a rectal spacer in the setting of LDR brachytherapy, providing the same benefits of anterior rectal wall protection but with improved visibility to facilitate correct contouring of the posterior prostate and rectal wall after the implant. To date, there exists minimal literature detailing the advantages of the SpaceOAR Vue™, and to the best of our knowledge, there are no prior reports of SpaceOAR Vue™ placement in the setting of LDR brachytherapy. Here we present a case series of 13 sequential patients with localized prostate cancer treated with LDR brachytherapy, either as monotherapy or as a boost in conjunction with EBRT, who underwent placement of SpaceOAR Vue™ at the time of implant.

Case Series Presentation

Thirteen male patients received definitive treatment for localized prostate cancer between November 2020 and July 2021 (Table 1). No patient had a history of an inflammatory bowel disease, other baseline auto-immune diagnoses, nor past abdominal or pelvic surgeries. Pathologic diagnoses were made based on 12-core transrectal ultrasound (TRUS)-guided biopsy, and the patients underwent diagnostic multiparametric MRI (mpMRI). All patients had clinical stage T1c-2c disease and Gleason scores 6–8 and were stage groups I and IIC. Pre-treatment PSA ranged between 4.78 and 10.27 ng/ml. A total of 54% of the patients had low- or favorable intermediate-risk disease and were treated with LDR monotherapy, and 46% had unfavorable intermediate- or high-risk disease and received brachytherapy as part of a boost at 1 to 2 weeks following EBRT (18). EBRT for those undergoing combination therapy was delivered to the prostate and seminal vesicles, with or without coverage of the pelvic lymph nodes depending on the calculated risk of involvement, prescribed up to 45 Gy in 1.8-Gy daily fractions using volumetric modulated arc therapy and daily cone beam CT. Androgen deprivation therapy, as indicated per national standards, was initiated approximately 2 months prior to EBRT.

TABLE 1
www.frontiersin.org

Table 1 Patient characteristics.

Brachytherapy preplanning was performed utilizing mpMRI (19). The mean prostate volume was 35.2 ± 8.1 cc (range, 26.6–53.1cc). Any radiographically identified high-grade (PIRADS 4 or 5) lesion (20) which corresponded to a positive region on diagnostic biopsy was contoured and planned for dose escalation of 150–200% of the prescription dose. SpaceOAR Vue™ was placed at the time of the brachytherapy implant (Figure 1B).

Among the patients treated, two were notable for clinical presentations in which SpaceOAR Vue™ had the potential to offer particular benefits. One was found to have two high-grade lesions, bilaterally concordant on mpMRI and biopsy, at the posterior boundary of the prostate at mid-gland (Figure 2A). A second patient had a metallic total hip replacement which generated substantial imaging artifact in the region of the prostate and rectal wall interface (Figure 2B).

FIGURE 2
www.frontiersin.org

Figure 2 (A) Bilateral posterior margin high-grade PIRADS lesion dose escalated to 200% of the prescription dose. (B) Patient with metallic left total hip replacement. Contours: blue, prostate gland; pink, SpaceOAR Vue™; brown, rectum; green, 100% isodose line; orange, 150% isodose line; maroon, 200% isodose line; aqua and light green, PIRADS lesions.

Methods

The implants were performed in an operating room setting under general anesthesia. Pre-operative weight-based antibiotics were given prophylactically. The patients were placed in the dorsal lithotomy position and prepped and draped in the usual sterile fashion. Using TRUS, multi-planar imaging of the prostate was obtained and captured in 5-mm increments from the base to the apex. These images were then intraoperatively fused to the preplanned T2-weighted MRI, and the MRI-based preplan was adjusted to account for observed variations in patient positioning. Employing this intraoperative plan as well as real-time planning with adaptive virtual dosimetry, I-125 radioactive seeds were transperineally placed under direct visualization with a modified peripheral loading technique. Definitive and boost cases were treated to doses of 145 and 110 Gy, respectively, prescribed to the periphery of the prostate gland per the current American Brachytherapy Society recommendations (18). MRI-visible high-grade PIRADS lesions were boosted up to 150–200% of the prescription dose. The mean number of needles and seeds required was 18.6 (range, 15–26) and 62.2 (range, 45–95), respectively.

After insertion of the final brachytherapy seed, the perineal grid was removed and the SpaceOAR Vue™ hydrogel was assembled. For patients who received an initial 45 Gy of EBRT, the ability to successfully hydrodissect the perirectal space was first confirmed using a 6-in. 18G needle and sterile saline prior to opening the hydrogel kit. SpaceOAR Vue™ placement was performed as previously described (12). The provided 18G needle was advanced under TRUS guidance, and the appropriate placement of the needle tip in the perirectal fat at midgland was confirmed in both axial and sagittal planes. Hydrodissection was performed to identify and open the potential space. The SpaceOAR Vue™ Y-connecter was then attached to the 18G needle, and the hydrogel components were deployed over approximately 10–12 s, taking into account the more viscous nature compared to the standard SpaceOAR™. The mean separation between the prostate and the rectum was 12.2 ± 2.1 mm (8.6–16.3mm), with a mean width of 29.0 mm (19.8–40.2mm) and length of 47.2 mm (34.3–64.9 mm).

Upon recovering from anesthesia, the patients underwent a same-day non-contrast CT (foley in place) for immediate post-operative dosimetry. All patients were discharged to home on the same day after independently voiding and were prescribed five additional days of prophylactic oral antibiotics as well as 0.8 mg of an α1 adrenergic antagonist (tamsulosin) to ease post-brachytherapy irritative urinary symptoms. Contouring of the prostate, urethra, rectum, and SpaceOAR Vue™ was performed in collaboration by the treating physician and the physicist. A favorable dose coverage of the prostate was achieved in all cases, with a mean prostate D90 of 113.8 ± 7.5% (range, 101.4–125.3%) and V100, V150, and V200 of 96 ± 2.4, 59.1 ± 11.5, and 31.7 ± 8.1%, respectively. Excellent rectal sparing was calculated, with a mean rectal D0.1cc, D1cc, and D2cc of 70.6, 49.6, and 41.8 of the prescribed dose, respectively.

No immediate procedure-related complications were reported within the week following brachytherapy. Toxicities were formally assessed at 1- and 3-month time periods. At 1-month follow-up, 54% of the patients experienced grade 2 urinary toxicity, and 46% had grade 0–1 urinary toxicity, comprised primarily of urgency and frequency, as expected. Relative to assessment at the time of presentation, there was a reported mean increase of 4.3 points on the International Prostate Symptom Score (IPSS) screening tool. By 3 months, only 38.5% maintained persistent grade 2 urinary toxicity, and the patients reported a mean decrease of 4 points in IPSS compared to baseline. At 1-month follow-up, 92% reported no rectal toxicities, with only one patient experiencing grade 1 mild diarrhea. The patients reported no rectal toxicities at 3 months post-brachytherapy.

Discussion

The dosimetric and clinical benefits of a rectal spacing hydrogel during radiation therapy in the treatment of prostate cancer are well documented (1214). To the best of our knowledge, this is the first report in the literature on the usage and advantages of iodinated SpaceOAR Vue™ in the setting of LDR brachytherapy for prostate cancer. In addition to the known benefit of displacing the anterior rectal wall away from the prostate and the high-dose region of radiation achieved with SpaceOAR™, the clear visibility of SpaceOAR Vue™ on CT makes it particularly beneficial for correctly identifying the precise boundaries of the posterior aspect of the prostate and anterior rectal wall in the unique context of post-implant dosimetry. Unlike with external radiation therapy, this anatomic region contains substantial CT artifact due to post-operative localized bleeding and edema as well as from the implanted metal seeds. We demonstrate even further benefit for patients who have a high-density hip implant, the effect of which can greatly obscure the anatomy of interest on CT.

Prior to recommending the addition of any invasive procedure to reduce potential risk, consideration must be given to the possible risks of the procedure itself as well as to the true extent of the purported benefit. While the overall risks of SpaceOAR™ insertion appear quite low, there have been documented reports of catastrophic complications, and because of that combined with remaining questions regarding the extent of the objective advantages across all patients treated for prostate cancer, responsible equipoise is appropriate in deciding to whom the device should be recommended (21). The specific population of patients in this report, wherein an invasive procedure was performed to implant a permanent dose far above that given with EBRT in close proximity to the adjacent rectum, perhaps represents one of the particular groups where the benefits of SpaceOAR™, and specifically SpaceOAR Vue™, emerge.

The risk of rectal toxicity from LDR brachytherapy is directly related to high-dose radiation exposure to sub-volumes of the rectum which is associated with the distance of the rectum to the brachytherapy seeds. The perirectal spacing and rectal dosimetry achieved in our series compare favorably with those of other recent reports of patients undergoing LDR brachytherapy with SpaceOAR™. In their retrospective series, Taggar et al. reported a mean separation of 11.2 mm, yielding a D1cc of the rectum at 25.3% in the context of good target coverage (prostate V100 and D90 of 94.0 and 112.4%, respectively (22), results which were comparable to those in our experience.

Kahn et al. reported rectal toxicities in patients receiving LDR brachytherapy with or without a PEG hydrogel rectal spacer (23). Patients with hydrogel placement had fewer acute grade 1 rectal toxicities reported at 1-month follow-up compared with those without hydrogel (12.5 vs. 17.5%). Among the 40 patients who did not have a hydrogel placed, one experienced delayed grade 2 rectal toxicity. The overall rates of grade 2+ rectal toxicity following LDR brachytherapy are low, ranging from 2.2 to 26% (weighted average of 7.9%) (2435). The reporting rates in aggregate is complicated by differing toxicity criteria used and variations in toxicity time points between studies. Furthermore, grade 1 toxicity is not commonly included but can contribute to decrements in the quality of life (36). In our series of SpaceOAR Vue™ placement, only one patient reported grade 1 rectal toxicity at 1 month, and none was reported at 3 months.

Certain clinical scenarios may especially benefit from the clearly visualized iodinated SpaceOAR Vue™. In addition to the hardening and streak artifact generated by the seeds themselves, the pelvic CT images of patients who have undergone metallic hip replacement surgery often show additional substantial artifact that can obscure the prostatic/rectal interface (Figures 2B, 3) (37). SpaceOAR Vue™, in this context, is uniquely capable of improving the ability to discern the precise boundary of the posterior aspect of the prostate and anterior rectal wall (Figure 3). A second scenario is when attempting to dose-escalate or boost a known region of high-grade disease (Figure 2A). This is an emerging technique which has been reported to improve the biochemical progression-free survival. In a series of prospective randomized controlled trials, FLAME and hypo-FLAME demonstrated feasibility, improved biochemical outcomes, and limited increases in acute toxicity with focal dose escalation of MRI-visible high-grade lesions (3840). Safely delivering such elevated doses even further requires accurate contouring and plan evaluation with regard to organs at risk. When delivering LDR brachytherapy, we typically boost mpMRI high-grade lesions concordant with biopsy results up to 150–200% of the prescription. Within this cohort, we highlight a particular case of bilateral posterior lesions in the prostate that were treated with this degree of dose escalation. SpaceOAR Vue™ allowed for improved accuracy in delineating the anterior rectal wall to assure an appropriate brachytherapy implant.

FIGURE 3
www.frontiersin.org

Figure 3 Comparison between SpaceOAR™ (A) and SpaceOAR Vue™ (B) in cases with artifact from total hip replacement.

Limitations

The limitations of this review include its inherent nature of being a retrospective case series and its lack of controlled comparison. Although an observational report, all 13 patients were treated by the same attending physician in collaboration with the same physicist, both with extensive experience in LDR brachytherapy, thereby reducing inter-patient planning, treatment, and contouring variability. A second limitation is the timeframe in which post-operative dosimetry was performed. Per the American Brachytherapy Society guidelines, post-operative dosimetry should be performed between days 0 and 60 from the procedure (18). The benefits of day 0 dosimetry include convenience, immediate information on the success of the implant, and enhancement of trainee education, while later dosimetry (days 30–60) allows for the resolution of edema and more accurately reflects the true deposited dose. As per department protocol, post-implant dosimetry was performed on day 0 for patients in this cohort. As such, there was more edema present during post-plan contouring and evaluation than would have been detected later. This schedule, however, is commonly followed in many practices and reflects a real-world clinical scenario in which SpaceOAR Vue™ can offer benefits.

Conclusion

SpaceOAR Vue™ offers additional benefits compared to the prior iteration of the hydrogel rectal spacer which is particularly advantageous in the unique context of LDR brachytherapy. It is not difficult to use, and like its predecessor, it results in significantly decreased high-dose radiation exposure to the rectal wall. Specifically, in the context of LDR brachytherapy where accurate post-op dosimetry is critical, the improved ability to identify the posterior aspect of the prostate and anterior rectal wall can offer improved radiation planning and therefore overall patient care. As such, we recommend the use of SpaceOAR Vue ™ in place of the standard SpaceOAR™ in cases of LDR brachytherapy utilized to treat patients with prostate cancer.

Data Availability Statement

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

Ethics Statement

The study involving human participants was reviewed and approved by the Internal Review Board of University Hospitals. The patients/participants provided their written informed consent to participate in this study. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.

Author Contributions

AG contributed to the writing of the manuscript and authored the initial draft. JY was the radiation physicist who assisted with all of the brachytherapy procedures, pre- and post-planning, was involved with creating figures as well as reviewed the manuscript. DS aided with the review of the manuscript. EF was the principal investigator who developed the concept for the article, performed the brachytherapy procedures, including reviewing and approving all pre- and post-plans, and drafted and revised the manuscript. All authors contributed to the article and approved the submitted version.

Funding

The publication of this manuscript was supported by Seidman Cancer Center, University Hospitals Cleveland Medical Center.

Conflict of Interest

EF is a paid speaker and consultant for Boston Scientific.

The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s Note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

References

1. Frank SJ, Levy LB, van Vulpen M, Crook J, Sylvester J, Grimm P, et al. Outcomes After Prostate Brachytherapy are Even Better Than Predicted. Cancer (2012) 118(3):839–47. doi: 10.1002/cncr.26307

PubMed Abstract | CrossRef Full Text | Google Scholar

2. Berlin A, Moraes FY, Sanmamed N, Glicksman R, Koven A, Espin-Garcia O, et al. International Multicenter Validation of an Intermediate Risk Subclassification of Prostate Cancer Managed With Radical Treatment Without Hormone Therapy. J Urol (2019) 201(2):284–91. doi: 10.1016/j.juro.2018.08.044

PubMed Abstract | CrossRef Full Text | Google Scholar

3. Giberti C, Chiono L, Gallo F, Schenone M, Gastaldi E. Radical Retropubic Prostatectomy Versus Brachytherapy for Low-Risk Prostatic Cancer: A Prospective Study. World J Urol (2009) 27(5):607–12. doi: 10.1007/s00345-009-0418-9

PubMed Abstract | CrossRef Full Text | Google Scholar

4. Giberti C, Gallo F, Schenone M, Gastaldi E, Cortese P, Ninotta G, et al. Robotic Prostatectomy Versus Brachytherapy for the Treatment of Low Risk Prostate Cancer. Can J Urol (2017) 24(2):8728–33.

PubMed Abstract | Google Scholar

5. Morris WJ, Tyldesley S, Rodda S, Halperin R, Pai H, McKenzie M, et al. Androgen Suppression Combined With Elective Nodal and Dose Escalated Radiation Therapy (the ASCENDE-RT Trial): An Analysis of Survival Endpoints for a Randomized Trial Comparing a Low-Dose-Rate Brachytherapy Boost to a Dose-Escalated External Beam Boost for High- and Intermediate-Risk Prostate Cancer. Int J Radiat Oncol Biol Phys (2017) 98(2):275–85. doi: 10.1016/j.ijrobp.2016.11.026

PubMed Abstract | CrossRef Full Text | Google Scholar

6. Stone NN, Potters L, Davis BJ, Ciezki JP, Zelefsky MJ, Roach M, et al. Multicenter Analysis of Effect of High Biologic Effective Dose on Biochemical Failure and Survival Outcomes in Patients With Gleason Score 7-10 Prostate Cancer Treated With Permanent Prostate Brachytherapy. Int J Radiat Oncol Biol Phys (2009) 73(2):341–6. doi: 10.1016/j.ijrobp.2008.04.038

PubMed Abstract | CrossRef Full Text | Google Scholar

7. Prestidge BR, Winter K, Sanda MG, Amin M, Bice Jr. WS, Michalski J, et al. Initial Report of NRG Oncology/RTOG 0232: A Phase 3 Study Comparing Combined External Beam Radiation and Transperineal Interstitial Permanent Brachytherapy With Brachytherapy Alone for Selected Patients With Intermediate-Risk Prostatic Carcinoma. Int J Radiat Oncol Biol Phys (2016) 96(2):S4. doi: 10.1016/j.ijrobp.2016.06.026

CrossRef Full Text | Google Scholar

8. Lawton CA, Hunt D, Lee WR, Gomella L, Grignon D, Gillin M, et al. Long-Term Results of a Phase II Trial of Ultrasound-Guided Radioactive Implantation of the Prostate for Definitive Management of Localized Adenocarcinoma of the Prostate (RTOG 98-05). Int J Radiat Oncol Biol Phys (2011) 81(1):1–7. doi: 10.1016/j.ijrobp.2010.05.056

PubMed Abstract | CrossRef Full Text | Google Scholar

9. Ohashi T, Yorozu A, Saito S, Tanaka N, Katayama N, Kojima S, et al. Urinary and Rectal Toxicity Profiles After Permanent Iodine-125 Implant Brachytherapy in Japanese Men: Nationwide J-POPS Multi-Institutional Prospective Cohort Study. Int J Radiat Oncol Biol Phys (2015) 93(1):141–9. doi: 10.1016/j.ijrobp.2015.05.014

PubMed Abstract | CrossRef Full Text | Google Scholar

10. Skolarus TA, Dunn RL, Sanda MG, Chang P, Greenfield TK, Litwin MS, et al. Minimally Important Difference for the Expanded Prostate Cancer Index Composite Short Form. Urology (2015) 85(1):101–5. doi: 10.1016/j.urology.2014.08.044

PubMed Abstract | CrossRef Full Text | Google Scholar

11. Zelefsky MJ, Kuban DA, Levy LB, Potters L, Beyer DC, Blasko JC, et al. Multi-Institutional Analysis of Long-Term Outcome for Stages T1-T2 Prostate Cancer Treated With Permanent Seed Implantation. Int J Radiat Oncol Biol Phys (2007) 67(2):327–33. doi: 10.1016/j.ijrobp.2006.08.056

PubMed Abstract | CrossRef Full Text | Google Scholar

12. Mariados N, Sylvester J, Shah D, Karsh L, Hudes R, Beyer D, et al. Hydrogel Spacer Prospective Multicenter Randomized Controlled Pivotal Trial: Dosimetric and Clinical Effects of Perirectal Spacer Application in Men Undergoing Prostate Image Guided Intensity Modulated Radiation Therapy. Int J Radiat Oncol Biol Phys (2015) 92(5):971–7. doi: 10.1016/j.ijrobp.2015.04.030

PubMed Abstract | CrossRef Full Text | Google Scholar

13. Seymour ZA, Hamstra DA, Daignault-Newton S, Bosch W, Michalski J, Gay HA, et al. Long-Term Follow-Up After Radiotherapy for Prostate Cancer With and Without Rectal Hydrogel Spacer: A Pooled Prospective Evaluation of Bowel-Associated Quality of Life. BJU Int (2020) 126(3):367–72. doi: 10.1111/bju.15097

PubMed Abstract | CrossRef Full Text | Google Scholar

14. Conroy D, Becht K, Forsthoefel M, Pepin AN, Lei S, Rashid A, et al. Utilization of Iodinated SpaceOAR Vue During Robotic Prostate Stereotactic Body Radiation Therapy (SBRT) to Identify the Rectal-Prostate Interface and Spare the Rectum: A Case Report. Front Oncol (2020) 10:607698. doi: 10.3389/fonc.2020.607698

PubMed Abstract | CrossRef Full Text | Google Scholar

15. Vaggers S, Rai BP, Chedgy ECP, de la Taille A, Somani BK. Polyethylene Glycol-Based Hydrogel Rectal Spacers for Prostate Brachytherapy: A Systematic Review With a Focus on Technique. World J Urol (2021) 39(6):1769–80. doi: 10.1007/s00345-020-03414-6

PubMed Abstract | CrossRef Full Text | Google Scholar

16. SpaceOAR(TM) FAQs. Why Have SpaceOAR?, Is SpaceOAR Necessary? Available at: https://www.spaceoar.com/about-spaceoar-hydrogel/faqs/ (Accessed October 20, 2021).

Google Scholar

17. Kamran SC, McClatchy 3DM, Pursley J, Trofimov AV, Remillard K, Saraf A, et al. Characterization of an Iodinated Rectal Spacer for Prostate Photon and Proton Radiation Therapy. Pract Radiat Oncol (2021) S1879–8500(21)00272-1. doi: 10.1016/j.prro.2021.09.009

PubMed Abstract | CrossRef Full Text | Google Scholar

18. Davis BJ, Horwitz EM, Lee WR, Crook JM, Stock RG, Merrick GS, et al. American Brachytherapy Society Consensus Guidelines for Transrectal Ultrasound-Guided Permanent Prostate Brachytherapy. Brachytherapy (2012) 11(1):6–19. doi: 10.1016/j.brachy.2011.07.005

PubMed Abstract | CrossRef Full Text | Google Scholar

19. Fredman ET, Traughber BJ, Gross A, Podder T, Colussi V, Vinkler R, et al. Comparison of Multiparametric MRI-Based and Transrectal Ultrasound-Based Preplans With Intraoperative Ultrasound-Based Planning for Low Dose Rate Interstitial Prostate Seed Implantation. J Appl Clin Med Phys (2019) 20(6):31–8. doi: 10.1002/acm2.12592

PubMed Abstract | CrossRef Full Text | Google Scholar

20. Turkbey B, Rosenkrantz AB, Haider MA, Padhani AR, Villeirs G, Macura KJ, et al. Prostate Imaging Reporting and Data System Version 2.1: 2019 Update of Prostate Imaging Reporting and Data System Version 2. Eur Urol (2019) 76(3):340–51. doi: 10.1016/j.eururo.2019.02.033

PubMed Abstract | CrossRef Full Text | Google Scholar

21. Hall WA, Tree AC, Dearnaley D, Parker CC, Prasad V, Roach 3M, et al. Considering Benefit and Risk Before Routinely Recommending SpaceOAR. Lancet Oncol (2021) 22(1):11–3. doi: 10.1016/S1470-2045(20)30639-2

PubMed Abstract | CrossRef Full Text | Google Scholar

22. Taggar AS, Charas T, Cohen GN, Boonyawan K, Kollmeier M, McBride S, et al. Placement of an Absorbable Rectal Hydrogel Spacer in Patients Undergoing Low-Dose-Rate Brachytherapy With Palladium-103. Brachytherapy (2018) 17(2):251–8. doi: 10.1016/j.brachy.2017.11.006

PubMed Abstract | CrossRef Full Text | Google Scholar

23. Kahn J, Dahman B, McLaughlin C, Kapoor P, Kapoor R, Harris E, et al. Rectal Spacing, Prostate Coverage, and Periprocedural Outcomes After Hydrogel Spacer Injection During Low-Dose-Rate Brachytherapy Implantation. Brachytherapy (2020) 19(2):228–33. doi: 10.1016/j.brachy.2019.11.002

PubMed Abstract | CrossRef Full Text | Google Scholar

24. Snyder KM, Stock RG, Hong SM, Lo YC, Stone NN. Defining the Risk of Developing Grade 2 Proctitis Following 125I Prostate Brachytherapy Using a Rectal Dose-Volume Histogram Analysis. Int J Radiat Oncol Biol Phys (2001) 50(2):335–41. doi: 10.1016/s0360-3016(01)01442-0

PubMed Abstract | CrossRef Full Text | Google Scholar

25. Gelblum DY, Potters L. Rectal Complications Associated With Transperineal Interstitial Brachytherapy for Prostate Cancer. Int J Radiat Oncol Biol Phys (2000) 48(1):119–24. doi: 10.1016/s0360-3016(00)00632-5

PubMed Abstract | CrossRef Full Text | Google Scholar

26. Zelefsky MJ, Hollister T, Raben A, Matthews S, Wallner KE. Five-Year Biochemical Outcome and Toxicity With Transperineal CT-Planned Permanent I-125 Prostate Implantation for Patients With Localized Prostate Cancer. Int J Radiat Oncol Biol Phys (2000) 47(5):1261–6. doi: 10.1016/s0360-3016(00)00550-2

PubMed Abstract | CrossRef Full Text | Google Scholar

27. Price JG, Stone NN, Stock RG. Predictive Factors and Management of Rectal Bleeding Side Effects Following Prostate Cancer Brachytherapy. Int J Radiat Oncol Biol Phys (2013) 86(5):842–7. doi: 10.1016/j.ijrobp.2013.04.033

PubMed Abstract | CrossRef Full Text | Google Scholar

28. Tran A, Wallner K, Merrick G, Seeberger J, Armstrong J, Mueller A, et al. Rectal Fistulas After Prostate Brachytherapy. Int J Radiat Oncol Biol Phys (2005) 63(1):150–4. doi: 10.1016/j.ijrobp.2005.01.021

PubMed Abstract | CrossRef Full Text | Google Scholar

29. Gomez-Iturriaga Pina A, Crook J, Borg J, Lockwood G, Fleshner N. Median 5 Year Follow-Up of 125iodine Brachytherapy as Monotherapy in Men Aged ≤ 55 Years With Favorable Prostate Cancer. Urology (2010) 75(6):1412–6. doi: 10.1016/j.urology.2009.04.101

PubMed Abstract | CrossRef Full Text | Google Scholar

30. Keyes M, Spadinger I, Liu M, Pickles T, Pai H, Hayden A, et al. Rectal Toxicity and Rectal Dosimetry in Low-Dose-Rate (125)I Permanent Prostate Implants: A Long-Term Study in 1006 Patients. Brachytherapy (2012) 11(3):199–208. doi: 10.1016/j.brachy.2011.05.007

PubMed Abstract | CrossRef Full Text | Google Scholar

31. Shiraishi Y, Yorozu A, Ohashi T, Toya K, Seki S, Yoshida K, et al. Dose Constraint for Minimizing Grade 2 Rectal Bleeding Following Brachytherapy Combined With External Beam Radiotherapy for Localized Prostate Cancer: Rectal Dose-Volume Histogram Analysis of 457 Patients. Int J Radiat Oncol Biol Phys (2011) 81(3):e127–33. doi: 10.1016/j.ijrobp.2011.01.012

PubMed Abstract | CrossRef Full Text | Google Scholar

32. Sherertz T, Wallner K, Merrick G, Ford E, Sutlief S, Cavanagh W, et al. Factors Predictive of Rectal Bleeding After 103Pd and Supplemental Beam Radiation for Prostate Cancer. Brachytherapy (2004) 3(3):130–5. doi: 10.1016/j.brachy.2004.05.005

PubMed Abstract | CrossRef Full Text | Google Scholar

33. Albert M, Tempany CM, Schultz D, Chen MH, Cormack RA, Kumar S, et al. Late Genitourinary and Gastrointestinal Toxicity After Magnetic Resonance Image-Guided Prostate Brachytherapy With or Without Neoadjuvant External Beam Radiation Therapy. Cancer (2003) 98(5):949–54. doi: 10.1002/cncr.11595

PubMed Abstract | CrossRef Full Text | Google Scholar

34. Duchesne GM, Williams SG, Das R, Tai KH. Patterns of Toxicity Following High-Dose-Rate Brachytherapy Boost for Prostate Cancer: Mature Prospective Phase I/II Study Results. Radiother Oncol (2007) 84(2):128–34. doi: 10.1016/j.radonc.2007.05.019

PubMed Abstract | CrossRef Full Text | Google Scholar

35. Zelefsky MJ, Yamada Y, Cohen GN, Shippy A, Chan H, Fridman D, et al. Five-Year Outcome of Intraoperative Conformal Permanent I-125 Interstitial Implantation for Patients With Clinically Localized Prostate Cancer. Int J Radiat Oncol Biol Phys (2007) 67(1):65–70. doi: 10.1016/j.ijrobp.2006.08.030

PubMed Abstract | CrossRef Full Text | Google Scholar

36. Rodda S, Morris WJ, Hamm J, Duncan G. ASCENDE-RT: An Analysis of Health-Related Quality of Life for a Randomized Trial Comparing Low-Dose-Rate Brachytherapy Boost With Dose-Escalated External Beam Boost for High- and Intermediate-Risk Prostate Cancer. Int J Radiat Oncol Biol Phys (2017) 98(3):581–9. doi: 10.1016/j.ijrobp.2017.02.027

PubMed Abstract | CrossRef Full Text | Google Scholar

37. Giantsoudi D, De Man B, Verburg J, Trofimov A, Jin Y, Wang G, et al. Metal Artifacts in Computed Tomography for Radiation Therapy Planning: Dosimetric Effects and Impact of Metal Artifact Reduction. Phys Med Biol (2017) 62(8):R49–80. doi: 10.1088/1361-6560/aa5293

PubMed Abstract | CrossRef Full Text | Google Scholar

38. Kerkmeijer LGW, Groen VH, Pos FJ, Haustermans K, Monninkhof EM, Smeenk RJ, et al. Focal Boost to the Intraprostatic Tumor in External Beam Radiotherapy for Patients With Localized Prostate Cancer: Results From the FLAME Randomized Phase III Trial. J Clin Oncol (2021) 39(7):787–96. doi: 10.1200/JCO.20.02873

PubMed Abstract | CrossRef Full Text | Google Scholar

39. Draulans C, van der Heide UA, Haustermans K, Pos FJ, van der Voort van Zyp J, De Boer H, et al. Primary Endpoint Analysis of the Multicentre Phase II Hypo-FLAME Trial for Intermediate and High Risk Prostate Cancer. Radiother Oncol (2020) 147:92–8. doi: 10.1016/j.radonc.2020.03.015

PubMed Abstract | CrossRef Full Text | Google Scholar

40. Feutren T, Herrera FG. Prostate Irradiation With Focal Dose Escalation to the Intraprostatic Dominant Nodule: A Systematic Review. Prostate Int (2018) 6(3):75–87. doi: 10.1016/j.prnil.2018.03.005

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: prostate cancer, brachytherapy, radiation, SpaceOAR Vue, toxicity

Citation: Gross A, Yuan J, Spratt D and Fredman E (2021) Case Report: Role of an Iodinated Rectal Hydrogel Spacer, SpaceOAR Vue™, in the Context of Low-Dose-Rate Prostate Brachytherapy, for Enhanced Post-Operative Contouring to Aid in Accurate Implant Evaluation and Dosimetry. Front. Oncol. 11:810955. doi: 10.3389/fonc.2021.810955

Received: 08 November 2021; Accepted: 23 November 2021;
Published: 22 December 2021.

Edited by:

Sean P. Collins, Georgetown University, United States

Reviewed by:

Sophia C. Kamran, Massachusetts General Hospital Cancer Center, United States
Darren James Leaning, James Cook University Hospital, United Kingdom

Copyright © 2021 Gross, Yuan, Spratt and Fredman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Elisha Fredman, efredman21@gmail.com

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.