AUTHOR=Chatzikonstantinou Thomas , Demosthenous Christos , Baliakas Panagiotis 

TITLE=Biology and Treatment of High-Risk CLL: Significance of Complex Karyotype

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.788761

DOI=10.3389/fonc.2021.788761

ISSN=2234-943X

ABSTRACT=<p>Several reports highlight the clinical significance of cytogenetic complexity, namely, complex karyotype (CK) identified though the performance of chromosome banding analysis (CBA) in chronic lymphocytic leukemia. Indeed, apart from a number of studies underscoring the prognostic and predictive value of CK in the chemo(immune)therapy era, mounting evidence suggests that CK could serve as an independent prognosticator and predictor even in patients treated with novel agents. In the present review, we provide an overview of the current knowledge regarding the clinical impact of CK in CLL, touching upon open issues related to the incorporation of CK in the clinical setting.</p>