AUTHOR=Wang Yichen , Zhang Qi , Tan Yufang , Lv Wenchang , Zhao Chongru , Xiong Mingchen , Hou Kai , Wu Min , Ren Yuping , Zeng Ning , Wu Yiping 

TITLE=Current Progress in Breast Implant-Associated Anaplastic Large Cell Lymphoma

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.785887

DOI=10.3389/fonc.2021.785887

ISSN=2234-943X

ABSTRACT=<p>Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is an uncommon type of T-cell lymphoma. Although with a low incidence, the epidemiological data raised the biosafety and health concerns of breast reconstruction and breast augmentation for BIA-ALCL. Emerging evidence confirms that genetic features, bacterial contamination, chronic inflammation, and textured breast implant are the relevant factors leading to the development of BIA-ALCL. Almost all reported cases with a medical history involve breast implants with a textured surface, which reflects the role of implant surface characteristics in BIA-ALCL. With this review, we expect to highlight the most significant features on etiology, pathogenesis, diagnosis, and therapy of BIA-ALCL, as well as we review the physical characteristics of breast implants and their potential pathogenic effect and hopefully provide a foundation for optimal choice of type of implant with minimal morbidity.</p>