AUTHOR=Yao Lin , Man Chang-Feng , He Rong , He Lian , Huang Jia-Bin , Xiang Shou-Yan , Dai Zhe , Wang Xiao-Yan , Fan Yu 

TITLE=The Interaction Between N6-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.784127

DOI=10.3389/fonc.2021.784127

ISSN=2234-943X

ABSTRACT=<p>N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most common epigenetic modification of eukaryotic RNA, which can participate in the growth and development of the body and a variety of physiological and disease processes by affecting the splicing, processing, localization, transport, translation, and degradation of RNA. Increasing evidence shows that non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, can also regulate the RNA m<sup>6</sup>A modification process by affecting the expression of m<sup>6</sup>A-related enzymes. The interaction between m<sup>6</sup>A modification and non-coding RNAs provides a new perspective for the exploration of the potential mechanism of tumor genesis and development. In this review, we summarize the potential mechanisms and effects of m<sup>6</sup>A and non-coding RNAs in gastrointestinal tract cancers.</p>