AUTHOR=Wang Ting , Li Zhaosheng , Yan Liujia , Yan Feng , Shen Han , Tian Xinyu 

TITLE=Long Non-Coding RNA Neighbor of BRCA1 Gene 2: A Crucial Regulator in Cancer Biology

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.783526

DOI=10.3389/fonc.2021.783526

ISSN=2234-943X

ABSTRACT=<p>Long non-coding RNAs (lncRNAs) are involved in fundamental biochemical and cellular processes. The neighbor of BRCA1 gene 2 (<italic>NBR2</italic>) is a long intergenic non-coding RNA (lincRNA) whose gene locus is adjacent to the tumor suppressor gene breast cancer susceptibility gene 1 (<italic>BRCA1</italic>). In human cancers, <italic>NBR2</italic> expression is dysregulated and correlates with clinical outcomes. Moreover, <italic>NBR2</italic> is crucial for glucose metabolism and affects the proliferation, survival, metastasis, and therapeutic resistance in different types of cancer. Here, we review the precise molecular mechanisms underlying <italic>NBR2</italic>-induced changes in cancer. In addition, the potential application of <italic>NBR2</italic> in the diagnosis and treatment of cancer is also discussed, as well as the challenges of exploiting <italic>NBR2</italic> for cancer intervention.</p>