AUTHOR=Lu Si , Yang Li-Xian , Cao Zi-Jian , Zhao Jiang-Sha , You Jia , Feng Yu-Xiong 

TITLE=Transcriptional Control of Metastasis by Integrated Stress Response Signaling

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.770843

DOI=10.3389/fonc.2021.770843

ISSN=2234-943X

ABSTRACT=<p>As a central cellular program to sense and transduce stress signals, the integrated stress response (ISR) pathway has been implicated in cancer initiation and progression. Depending on the genetic mutation landscape, cellular context, and differentiation states, there are emerging pieces of evidence showing that blockage of the ISR can selectively and effectively shift the balance of cancer cells toward apoptosis, rendering the ISR a promising target in cancer therapy. Going beyond its pro-survival functions, the ISR can also influence metastasis, especially <italic>via</italic> proteostasis-independent mechanisms. In particular, ISR can modulate metastasis <italic>via</italic> transcriptional reprogramming, in the help of essential transcription factors. In this review, we summarized the current understandings of ISR in cancer metastasis from the perspective of transcriptional regulation.</p>