AUTHOR=Yu Hua , Bai Ying , Qiu Jing , He Xiaomei , Xiong Junzhi , Dai Qian , Wang Xingmin , Li Yuanyuan , Sheng Halei , Xin Rong , Jiang Lu , Li Qiaoqiao , Li Defeng , Zhang Hong , Zhang Le , Chen Qian , Peng Jin , Hu Xiaomei , Zhang Kebin TITLE=Pseudomonas aeruginosa PcrV Enhances the Nitric Oxide-Mediated Tumoricidal Activity of Tumor-Associated Macrophages via a TLR4/PI3K/AKT/mTOR-Glycolysis-Nitric Oxide Circuit JOURNAL=Frontiers in Oncology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.736882 DOI=10.3389/fonc.2021.736882 ISSN=2234-943X ABSTRACT=
Tumor-associated macrophages (TAMs), which display a tumor-supportive M2 phenotype, are closely related to tumor growth and metastasis. The reprogramming of TAMs toward a tumoricidal M1 profile has emerged as an attractive strategy for cancer immunotherapy. In this study, we found that the intratumoral injection of PcrV protein, a component of the