AUTHOR=Duan Xiaoye , Wang Weihao , Pan Qi , Guo Lixin 

TITLE=Type 2 Diabetes Mellitus Intersects With Pancreatic Cancer Diagnosis and Development

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.730038

DOI=10.3389/fonc.2021.730038

ISSN=2234-943X

ABSTRACT=<p>The relationship between type 2 diabetes mellitus (T2DM) and pancreatic cancer (PC) is complex. Diabetes is a known risk factor for PC, and new-onset diabetes (NOD) could be an early manifestation of PC that may be facilitate the early diagnosis of PC. Metformin offers a clear benefit of inhibiting PC, whereas insulin therapy may increase the risk of PC development. No evidence has shown that novel hypoglycemic drugs help or prevent PC. In this review, the effects of T2DM on PC development are summarized, and novel strategies for the prevention and treatment of T2DM and PC are discussed.</p>