AUTHOR=Zeng Hao , Li Yalun , Wang Ye , Huang Meijuan , Zhang Yan , Tian Panwen , Li Weimin 

TITLE=Case Report: Identification of Two Rare Fusions, PDK1-ALK and STRN-ALK, That Coexist in a Lung Adenocarcinoma Patient and the Response to Alectinib

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.722843

DOI=10.3389/fonc.2021.722843

ISSN=2234-943X

ABSTRACT=<p>Several double <italic>ALK</italic> fusions coexisting in one patient have been reported. However, few studies have reported the clinical efficacy of ALK inhibitors in rare double <italic>ALK</italic> fusions. Here, we described a rare <italic>PDK1-ALK</italic>, <italic>STRN-ALK</italic> double-fusion variant in a patient with metastatic lung adenocarcinoma. The patient responded well to alectinib (600 mg) twice daily. This case shows a promising treatment option for patients with rare <italic>ALK</italic> double-fusion variants.</p>