AUTHOR=Li Yang , Liu Yang , Yin Ping , Hao Chuanxi , Sun Chao , Chen Lei , Wang Sicong , Hong Nan 

TITLE=MRI-Based Bone Marrow Radiomics Nomogram for Prediction of Overall Survival in Patients With Multiple Myeloma

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.709813

DOI=10.3389/fonc.2021.709813

ISSN=2234-943X

ABSTRACT=<sec><title>Purpose</title><p>To develop and validate a radiomics nomogram for predicting overall survival (OS) in multiple myeloma (MM) patients.</p></sec><sec><title>Material and Methods</title><p>A total of 121 MM patients was enrolled and divided into training (n=84) and validation (n=37) sets. The radiomics signature was established by the selected radiomics features from lumbar MRI. The radiomics signature and clinical risk factors were integrated in multivariate Cox regression model for constructing radiomics nomogram to predict MM OS. The predictive ability and accuracy of the nomogram were evaluated by the index of concordance (C-index) and calibration curves, and compared with other four models including the clinical model, radiomics signature model, the Durie-Salmon staging system (D-S) and the International Staging System (ISS). The potential association between the radiomics signature and progression-free survival (PFS) was also explored.</p></sec><sec><title>Results</title><p>The radiomics signature, 1q21 gain, del (17p), and β2-MG≥5.5 mg/L showed significant association with MM OS. The predictive ability of radiomics nomogram was better than the clinical model, radiomics signature model, the D-S and the ISS (C-index: 0.793 <italic>vs</italic>. 0.733 <italic>vs</italic>. 0.742 <italic>vs</italic>. 0.554 <italic>vs</italic>. 0.671 in training set, and 0.812 <italic>vs</italic>. 0.799 vs.0.717 <italic>vs</italic>. 0.512 <italic>vs</italic>. 0.761 in validation set). The radiomics signature lacked the predictive ability for PFS (log-rank <italic>P</italic>=0.001 in training set and log-rank <italic>P</italic>=0.103 in validation set), whereas the 1-, 2- and 3-year PFS rates all showed significant difference between the high and low risk groups (<italic>P ≤</italic> 0.05).</p></sec><sec><title>Conclusion</title><p>The MRI-based bone marrow radiomics may be an additional useful tool for MM OS prediction.</p></sec>