AUTHOR=Pu Xingxiang , Yang Sa , Xu Yan , Chen Bolin , Wang Qianzhi , Gong Qian , Wu Lin 

TITLE=Case Report: Tissue Origin Identification for Cancer of Unknown Primary: Gene Expression Profiling Approach

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.702887

DOI=10.3389/fonc.2021.702887

ISSN=2234-943X

ABSTRACT=<p>The treatment of cancer of unknown primary (CUP) is a huge challenge for clinicians. Gene expression profiling can help identify the tissue origin of tumors by detecting the expression levels of specific genes in tumor tissues. Herein, we report four CUP cases. All of them have been successfully identified with the corresponding primary tumor sites through gene expression profiling analysis. Then all patients received accurate treatment, providing reference to guide therapeutic decisions to treat CUP tumors in the future.</p>