AUTHOR=Hamed Motaz , Schäfer Niklas , Bode Christian , Borger Valeri , Potthoff Anna-Laura , Eichhorn Lars , Giordano Frank A. , Güresir Erdem , Heimann Muriel , Ko Yon-Dschun , Landsberg Jennifer , Lehmann Felix , Radbruch Alexander , Scharnböck Elisa , Schaub Christina , Schwab Katjana S. , Weller Johannes , Herrlinger Ulrich , Vatter Hartmut , Schuss Patrick , Schneider Matthias 

TITLE=Preoperative Metastatic Brain Tumor-Associated Intracerebral Hemorrhage Is Associated With Dismal Prognosis

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.699860

DOI=10.3389/fonc.2021.699860

ISSN=2234-943X

ABSTRACT=<sec><title>Object</title><p>Intra-tumoral hemorrhage is considered an imaging characteristic of advanced cancer disease. However, data on the influence of intra-tumoral hemorrhage in patients with brain metastases (BM) remains scarce. We aimed at investigating patients with BM who underwent neurosurgical resection of the metastatic lesion for a potential impact of preoperative hemorrhagic transformation on overall survival (OS).</p></sec><sec><title>Methods</title><p>Between 2013 and 2018, 357 patients with BM were surgically treated at the authors’ neuro-oncological center. Preoperative magnetic resonance imaging (MRI) examinations were assessed for the occurrence of malignant hemorrhagic transformation.</p></sec><sec><title>Results</title><p>122 of 375 patients (34%) with BM revealed preoperative intra-tumoral hemorrhage. Patients with hemorrhagic transformed BM exhibited a median OS of 5 months compared to 12 months for patients without intra-tumoral hemorrhage. Multivariate analysis revealed preoperative hemorrhagic transformation as an independent and significant predictor for worsened OS.</p></sec><sec><title>Conclusions</title><p>The present study identifies preoperative intra-tumoral hemorrhage as an indicator variable for poor prognosis in patients with BM undergoing neurosurgical treatment.</p></sec>