AUTHOR=Capodanno Isabella , Lugli Elisabetta , Codeluppi Katia , Faruolo Mariapina , Bellesia Enrica , Valli Riccardo , Merli Francesco 

TITLE=Accelerated Phase Chronic Myeloid Leukemia and Treatment Free Remission Maintained After Five Years of Nilotinib: A Case Report

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.696253

DOI=10.3389/fonc.2021.696253

ISSN=2234-943X

ABSTRACT=<p>The present article reports the case of a patient presenting with chronic myeloid leukemia, diagnosed during the accelerated phase (&gt;20% blasts in peripheral blood samples and megakaryocyte agglomerates in the bone marrow). The subject was treated with first-line therapy with the tyrosine kinase inhibitor nilotinib and reached complete clinical and molecular remission (according to the European Leukemia Net-ELN-criteria), which persisted over five years of treatment. Five years after discontinuation of nilotinib (ten years from diagnosis), the patient is in good clinical condition, with no traces of BCL-ABL1 at molecular evaluation (molecular response, MR<sup>5</sup>). The case is discussed in the setting of current literature, providing an overview on chronic myeloid leukemia and a discussion on treatment options available.</p>