AUTHOR=Grard Marion , Chatelain Camille , Delaunay Tiphaine , Pons-Tostivint Elvire , Bennouna Jaafar , Fonteneau Jean-François 

TITLE=Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.695770

DOI=10.3389/fonc.2021.695770

ISSN=2234-943X

ABSTRACT=<p>Homozygous deletion (HD) of the tumor suppressor gene <italic>CDKN2A</italic> is the most frequent genetic alteration in malignant pleural mesothelioma and is also frequent in non-small cell lung cancers. This HD is often accompanied by the HD of the type I interferons (IFN I) genes that are located closed to the <italic>CDKN2A</italic> gene on the p21.3 region of chromosome 9. IFN I genes encode sixteen cytokines (IFN-α, IFN-β…) that are implicated in cellular antiviral and antitumor defense and in the induction of the immune response. In this review, we discuss the potential influence of IFN I genes HD on thoracic cancers therapy and speak in favor of better taking these HD into account in patients monitoring.</p>