AUTHOR=Xu Juan , Chen Xiyi , Sun Yu , Shi Yaqian , Teng Fang , Lv Mingming , Liu Chen , Jia Xuemei 

TITLE=The Regulation Network and Clinical Significance of Circular RNAs in Breast Cancer

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.691317

DOI=10.3389/fonc.2021.691317

ISSN=2234-943X

ABSTRACT=<p>Breast cancer is one of the most common malignant tumors in women worldwide. Circular RNA (circRNA) is a class of structurally stable non-coding RNA with a covalently closed circular structure. In recent years, with the development of high-throughput RNA sequencing, many circRNAs have been discovered and have proven to be clinically significant in the development and progression of breast cancer. Importantly, several regulators of circRNA biogenesis have been discovered. Here, we systematically summarize recent progress regarding the network of regulation governing the biogenesis, degradation, and distribution of circRNAs, and we comprehensively analyze the functions, mechanisms, and clinical significance of circRNA in breast cancer.</p>