AUTHOR=Shao Liang , Xu Chengshi , Wu Huijing , Jamal Muhammad , Pan Shan , Li Sirui , Chen Fei , Yu Ding , Liu Kui , Wei Yongchang TITLE=Recent Progress on Primary Central Nervous System Lymphoma—From Bench to Bedside JOURNAL=Frontiers in Oncology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.689843 DOI=10.3389/fonc.2021.689843 ISSN=2234-943X ABSTRACT=

Primary central nervous system lymphoma (PCNSL) is a rare subtype of extra-nodal lymphoma. The high relapse rate of PCNSL remains a major challenge to the hematologists, even though patients exhibit high sensitivity to the methotrexate-based chemotherapeutic regimens. Recently, the advent of Bruton’s tyrosine kinase inhibitor (BTKi) and CAR T treatment has made more treatment options available to a proportion of patients. However, whether BTKi monotherapy should be given alone or in combination with conventional chemotherapy is still a clinical question. The status of CAR T therapy for PCNSLs also needs to be elucidated. In this review, we summarized the latest progress on the epidemiology, pathology, clinical manifestation, diagnosis, and treatment options for PCNSLs.