AUTHOR=Li Ying , Ma Jun , Song Ziteng , Zhao Yinan , Zhang Han , Li Yeling , Xu Jing , Guo Yuanqiang 

TITLE=The Antitumor Activity and Mechanism of a Natural Diterpenoid From Casearia graveolens

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.688195

DOI=10.3389/fonc.2021.688195

ISSN=2234-943X

ABSTRACT=<p>Casearlucin A, a diterpenoid obtained from <italic>Casearia graveolens</italic>, has been reported to possess strong cytotoxic activity. However, the <italic>in vivo</italic> anti-tumor effects and the action mechanism of casearlucin A remain poorly understood. Our study revealed that casearlucin A arrested cell cycle at G0/G1 stage and induced cell apoptosis in cell level. Additionally, casearlucin A inhibited HepG2 cell migration <italic>via</italic> regulating a few of metastasis-related proteins. Furthermore, it inhibited tumor angiogenesis in zebrafish <italic>in vivo</italic>. More importantly, casearlucin A significantly inhibited cell proliferation and migration in an <italic>in vivo</italic> zebrafish xenograft model. Collectively, these results are valuable for the further development and application of casearlucin A as an anticancer agent.</p>