AUTHOR=Takahashi Naoki , Tajiri Kazuto , Kagoyana Ko , Tanaka Shinichi , Yasuda Ichiro 

TITLE=CD8 Positive T Lymphocyte Infiltration of Liver Metastases of Uveal Melanoma: A Case Report

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.672660

DOI=10.3389/fonc.2021.672660

ISSN=2234-943X

ABSTRACT=<p>A 78-year-old Japanese man was referred for examination of multiple small nodules on his liver detected by magnetic resonance imaging (MRI). These small nodules were hyperintense on T1-weighted MRI, and were in hepatobiliary phase on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced MRI. Five years earlier, he had undergone curative enucleation of his left eye for uveal melanoma. US-guided biopsy revealed that the liver nodules were metastases of melanoma. Pathological examination also showed infiltration of CD8 positive T lymphocytes. The metastatic nodules remained unchanged for more than 2 years and he was not further treated. This pathology and clinical course suggest that the systemic immune response of the host could suppress hepatic metastases of uveal melanoma.</p>