AUTHOR=Shen Junwen , Wang Rongjiang , Chen Yu , Fang Zhihai , Tang Jianer , Yao Jianxiang , Ling Yuhang , Zhang Lisha , Zhang Xu 

TITLE=An Immune-Related Signature Predicted Survival in Patients With Kidney Papillary Cell Carcinoma

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.670047

DOI=10.3389/fonc.2021.670047

ISSN=2234-943X

ABSTRACT=<p>Immune-related genes are important factors in tumor progression. The main aim of this study was to identify the immune-related genes in kidney papillary cell carcinoma (pRCC) patients. We downloaded RNAseq data and clinical information of pRCC patients from the TCGA database and retrieved the immune-related genes list from Immport. From the data, we mined out 2,468 differential expression genes (DEGs) and 183 immune-related DEGs. Four hub DEGs (<italic>NTS</italic>, <italic>BIRC5</italic>, <italic>ELN</italic>, and <italic>CHGA</italic>) were identified after conducting Cox analysis and LASSO analysis. Moreover, the prognostic value of the signature based on four hub DEGs was verified using Kaplan–Meier analysis (P = 0.0041 in the training set and p = 0.021 in the test set) and ROC analysis (AUC: 0.957 in 1 year, 0.965 in 2 years, and 0.901 in 3 years in the training set, and 0.963 in 1 year, 0.898 in 2 years, and 0.742 in 3 years in the test set). Furthermore, we found that the high-risk score group had a higher percentage of B cells in the immune component, a higher expression of immune-related genes (<italic>CTLA4</italic>, <italic>LAG3</italic>, <italic>PDCD1LG2</italic>, and <italic>TIGIT</italic>), and a better immunotherapy response.</p>