AUTHOR=Zhang Caihui , Xie Cuiyu , Lu Yao TITLE=Local Anesthetic Lidocaine and Cancer: Insight Into Tumor Progression and Recurrence JOURNAL=Frontiers in Oncology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.669746 DOI=10.3389/fonc.2021.669746 ISSN=2234-943X ABSTRACT=
Cancer is a leading contributor to deaths worldwide. Surgery is the primary treatment for resectable cancers. Nonetheless, it also results in inflammatory response, angiogenesis, and stimulated metastasis. Local anesthetic lidocaine can directly and indirectly effect different cancers. The direct mechanisms are inhibiting proliferation and inducing apoptosis