AUTHOR=Di Battista Piero , Lovisa Federica , Gaffo Enrico , Gallingani Ilaria , Damanti Carlotta C. , Garbin Anna , Ferrone Lavinia , Carraro Elisa , Pillon Marta , Lo Nigro Luca , Mura Rossella , Pizzi Marco , Guzzardo Vincenza , Dei Tos Angelo Paolo , Biffi Alessandra , Bortoluzzi Stefania , Mussolin Lara 

TITLE=Low miR-214-5p Expression Correlates With Aggressive Subtypes of Pediatric ALCL With Non-Common Histology

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.663221

DOI=10.3389/fonc.2021.663221

ISSN=2234-943X

ABSTRACT=<p>The unsatisfactory cure rate of relapsing ALK-positive Anaplastic Large-Cell Lymphoma (ALCL) of childhood calls for the identification of new prognostic markers. Here, the small RNA landscape of pediatric ALK-positive ALCL was defined by RNA sequencing. Overall, 121 miRNAs were significantly dysregulated in ALCL compared to non-neoplastic lymph nodes. The most up-regulated miRNA was miR-21-5p, whereas miR-19a-3p and miR-214-5p were reduced in ALCL. Characterization of miRNA expression in cases that relapsed after first line therapy disclosed a significant association between miR-214-5p down-regulation and aggressive non-common histology. Our results suggest that miR-214-5p level may help to refine the prognostic stratification of pediatric ALK-positive ALCL.</p>