AUTHOR=Yang Jun , Gong Chaoju , Ke Qinjian , Fang Zejun , Chen Xiaowen , Ye Ming , Xu Xi 

TITLE=Insights Into the Function and Clinical Application of HDAC5 in Cancer Management

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.661620

DOI=10.3389/fonc.2021.661620

ISSN=2234-943X

ABSTRACT=<p>Histone deacetylase 5 (HDAC5) is a class II HDAC. Aberrant expression of HDAC5 has been observed in multiple cancer types, and its functions in cell proliferation and invasion, the immune response, and maintenance of stemness have been widely studied. HDAC5 is considered as a reliable therapeutic target for anticancer drugs. In light of recent findings regarding the role of epigenetic reprogramming in tumorigenesis, in this review, we provide an overview of the expression, biological functions, regulatory mechanisms, and clinical significance of HDAC5 in cancer.</p>