AUTHOR=Wang Yuxin 

TITLE=LRRC3B Polymorphisms Contributed to Breast Cancer Susceptibility in Chinese Han Population

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.657168

DOI=10.3389/fonc.2021.657168

ISSN=2234-943X

ABSTRACT=<sec><title>Purpose</title><p><italic>LRRC3B</italic> gene, as a tumor suppressor gene was involved in the development and progress of breast cancer (BC). However, the effect of <italic>LRRC3B</italic> polymorphisms on BC has rarely been reported. In the study, we aimed to evaluate the relation between <italic>LRRC3B</italic> variants and BC risk.</p></sec><sec><title>Methods</title><p>Among 563 BC patients and 552 healthy controls, ten single-nucleotide polymorphisms (SNPs) in <italic>LRRC3B</italic> were genotyped by Agena MassARRAY. Odds ratios (ORs) and 95% confidence interval (CI) were calculated using logistic regression model.</p></sec><sec><title>Results</title><p>Our study demonstrated that rs1907168 polymorphism (heterozygous: OR = 0.71, <italic>p</italic> = 0.017) was related to the reduced risk of BC in the overall. In stratified analyses by age, rs1907168 was associated with the decreased (heterozygous: OR = 0.53, <italic>p</italic> = 0.002) while rs78205284 (homozygote: OR = 2.83, <italic>p</italic> = 0.034) increased BC susceptibility among the population at age ≤51 years. Rs6551122 (recessive: OR = 0.51, <italic>p</italic> = 0.028) and rs12635768 (homozygote, OR = 0.36, <italic>p</italic> = 0.023) polymorphisms were related to the smaller BC tumor size (&lt;2 cm). In addition, rs112276562 (heterozygote OR = 0.56, <italic>p</italic> = 0.002), rs6551122 (heterozygote OR = 0.63, <italic>p</italic> = 0.016), and rs73150416 (heterozygote OR = 0.57, <italic>p</italic> = 0.005) variants contributed to the lower incidence of PR-positive BC. Moreover, rs6788033 was associated with a lower expression level of Ki-67 (log-additive: OR = 0.68, <italic>p</italic> = 0.024). Furthermore, we found an association of ‘GATT’ haplotype with an increased risk for BC. In addition, <italic>LRRC3B</italic> gene was down-regulated in BC tumor and had a poor prognosis in BC in <italic>in silico</italic> analysis.</p></sec><sec><title>Conclusion</title><p>Our study firstly found <italic>LRRC3B</italic> SNPs contributed to the risk of BC, suggesting <italic>LRRC3B</italic> variants might help to predict BC progression.</p></sec>