AUTHOR=Zhu Xinyu , Feng Yanlin , He Dingdong , Wang Zi , Huang Fangfang , Tu Jiancheng 

TITLE=Clinical Value and Underlying Mechanisms of Upregulated LINC00485 in Hepatocellular Carcinoma

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.654424

DOI=10.3389/fonc.2021.654424

ISSN=2234-943X

ABSTRACT=<sec><title>Aims</title><p>This study aimed to reveal the functional role of <italic>LINC00485</italic> in hepatocellular carcinoma (HCC).</p></sec><sec><title>Materials &amp; Methods</title><p>210 serum samples from Zhongnan Hospital of Wuhan University were employed to evaluate clinical value of <italic>LINC00485</italic>. Bioinformatics analysis was adopted to explore its potential mechanisms.</p></sec><sec><title>Results</title><p><italic>LINC00485</italic> was confirmed to be upregulated in HCC tissues and serum samples. Survival analysis and receiver operating characteristic curve revealed its prognostic and diagnostic roles. The combination of serum <italic>LINC00485</italic> with AFP can remarkably improve diagnostic ability of HCC. Exploration of the underlying mechanism demonstrated that <italic>LINC00485</italic> might exert pro-oncogenic activity by <italic>LINC00485</italic>—three miRNAs—four mRNAs network.</p></sec><sec><title>Conclusions</title><p>Our study unveiled that upregulated <italic>LINC00485</italic> could act as a potential diagnostic and prognostic biomarker and provide a novel insight into the molecular mechanisms of <italic>LINC00485</italic> in HCC pathogenesis.</p></sec>