AUTHOR=Ma Danhui , Chen Sinuo , Wang Heming , Wei Jiayi , Wu Hao , Gao Hong , Cheng Xinlai , Liu Taotao , Luo Shi-Hua , Zhao Yicheng , Song Guangqi TITLE=Baicalein Induces Apoptosis of Pancreatic Cancer Cells by Regulating the Expression of miR-139-3p and miR-196b-5p JOURNAL=Frontiers in Oncology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.653061 DOI=10.3389/fonc.2021.653061 ISSN=2234-943X ABSTRACT=
Pancreatic cancer is a common malignant tumor with a high incidence and mortality rate. The prognosis of patients with pancreatic cancer is considerably poor due to the lack of effective treatment in clinically. Despite numerous studies have revealed that baicalein, a natural product, is responsible for suppressing multiple cancer cells proliferation, motility and invasion. The mechanism by which baicalein restraining pancreatic cancer progression remains unclear. In this study, we firstly verified that baicalein plays a critical role in inhibiting pancreatic tumorigenesis