AUTHOR=Shen Jiahui , Jiang Yanhui , Wu Fengzhi , Chen Hui , Wu Qiujing , Zang Xiaoxiao , Chen Le , Chen Yong , Yuan Qiwen 

TITLE=Correlation Analysis Between MTHFR C677T Polymorphism and Uterine Fibroids: A Retrospective Cohort Study

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.648794

DOI=10.3389/fonc.2021.648794

ISSN=2234-943X

ABSTRACT=<sec><title>Background</title><p>Uterine fibroids(UF) are the most common benign tumors in women, with high incidence and unknown causes. We aimed to explore the correlation between Methylenetetra-hydrofolate reductase (<italic>MTHFR</italic>) <italic>C677T</italic> polymorphism and UF.</p></sec><sec><title>Methods</title><p>This is a retrospective cohort study. Data were collected from 2411 women detected for <italic>MTHFR C677T</italic> polymorphism in the Fifth Affiliated Hospital of Sun Yat-sen University from 2018 to 2020. B-ultrasound (BU) and the first page of medical records were used to analyze whether they had ever been diagnosed with UF. The collected data were analyzed. Using the chi-square test and regression analysis to explore the correlation, and the risk factors was screened by multifactor logistic regression analysis.</p></sec><sec><title>Results</title><p>A total of 2411 pregnant women were in the <italic>MTHFR C677T</italic> polymorphism detection. Among them, 226(9.37%) were diagnosed as UF by BU or clinical diagnosis. The allele and genotype of <italic>MTHFR C677T</italic> were significantly different between the case and control group (p&lt;0.05), and the distribution of the allele was following Hardy-Weinberg (H-W) equilibrium. Comparing with the wild-type (<italic>C/C</italic>), the mutant group (<italic>C/T+T/T</italic>) was more likely to form UF(OR,1.43;OR95%CI,1.07-1.89). After adjusting for confoundings, the heterozygous mutant (<italic>C/T</italic>) was more susceptible to UF than the wild-type (aOR,1.41;aOR95%CI,1.41-1.91). In the case group, BMI, gravidity and parity were not associated with the size and number of UF and the <italic>MTHFR C677T</italic> polymorphism (p&gt;0.05). However, older maternal age was associated with the incidence of UF, especially the multiple UF (p&lt;0.05).</p></sec><sec><title>Conclusion</title><p>Our results found that <italic>MTHFR C677T</italic> polymorphism was associated with UF occurrence for the first time. This could imply that it may increase the risk of forming UF in women of gestational age.</p></sec>