AUTHOR=Qin Miaomiao , Wang Danping , Fang Yijiao , Zheng Zhiying , Liu Xinyang , Wu Fan , Wang Liangliang , Li Xiao , Hui Bingqing , Ma Shijie , Tang Weiwei , Pan Xiongxiong 

TITLE=Current Perspectives on B Lymphocytes in the Immunobiology of Hepatocellular Carcinoma

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.647854

DOI=10.3389/fonc.2021.647854

ISSN=2234-943X

ABSTRACT=<p>Immune cells infiltrating tumors are capable of significantly impacting carcinogenesis through cancer promotion and anticancer responses. There are many aspects of hepatocellular carcinoma (HCC) related T lymphocytes that are undergoing extensive studies, whereas the effect exerted by B lymphocytes remains a less researched area. In this study, the latest research on the effect of B lymphocytes as they infiltrate tumors in relation to HCC is presented. Their prognosis-related importance is analyzed, along with their function in the tumor microenvironment (TME), as well as the way that B cell biology can be employed to help create a B cell therapy strategy for HCC.</p>