AUTHOR=Zhang Yao , Xiao Chao , Li Jing , Song Lu-xi , Zhao You-shan , Han Shuang , Li Zhao-wei , Guo Cha , Zhao Jun-gong , Chang Chun-kang 

TITLE=Comparative Study on Iron Content Detection by Energy Spectral CT and MRI in MDS Patients

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.646946

DOI=10.3389/fonc.2021.646946

ISSN=2234-943X

ABSTRACT=<p><bold>Objective:</bold> The purpose of this study was to identify the difference between dual energy spectral computed tomography (DECT) and magnetic resonance imaging (MRI) used to detect liver/cardiac iron content in Myelodysplastic syndrome (MDS) patients with differently adjusted serum ferritin (ASF) levels.</p><p><bold>Method:</bold> Liver and cardiac iron content were detected by DECT and MRI. Patients were divided into different subgroups according to the level of ASF. The receiver operating characteristic curve (ROC) analysis was applied in each subgroup. The correlation between iron content detected by DECT/MRI and ASF was analyzed in each subgroup.</p><p><bold>Result:</bold> ROC curves showed that liver virtual iron content (LVIC) <italic>Az</italic> was significantly less than liver iron concentration (LIC) <italic>Az</italic> in the subgroup with ASF &lt; 1,000 ng/ml. There was no significant difference between LVIC <italic>Az</italic> and LIC <italic>Az</italic> in the subgroup with 1,000 ≤ ASF &lt; 2,500 ng/ml and 2,500 ≤ ASF &lt; 5,000 ng/ml. LVIC <italic>Az</italic> was significantly higher than LIC <italic>Az</italic> in the subgroup with ASF &lt;5,000 and 5,000 ≤ ASF ng/ml. In patients undergoing DECT and MRI examination on the same day, ASF was significantly correlated with LVIC, whereas no significant correlation was observed between ASF and LIC. After removing the data of ASF &gt; 5,000 mg/L in LIC, LIC became correlated with ASF. There was no significant difference between the subgroup with 2,500 ≤ ASF &lt; 5,000 ng/ml and 5,000 ng/ml ≤ ASF in LIC expression. Furthermore, both LIC and liver VIC had significant correlations with ASF in patients with ASF &lt; 2,500 ng/ml, while LVIC was still correlated with ASF, LIC was not correlated with ASF in patients with 2,500 ng/ml ≤ ASF. Moreover, neither cardiac VIC nor myocardial iron content (MIC) were correlated with ASF in these subgroups.</p><p><bold>Conclusion:</bold> MRI and DECT were complementary to each other in liver iron detection. In MDS patients with high iron content, such as ASF ≥ 5,000 ng/ml, DECT was more reliable than the MRI in the assessment of iron content. But in patients with low iron content, such as ASF &lt; 1,000 ng/ml, MRI is more reliable than DECT. Therefore, for the sake of more accurately evaluating the iron content, the appropriate detection method can be selected according to ASF.</p>