AUTHOR=Tang Chun , Wang Xuehui , Ji Changle , Zheng Wenfang , Yu Yunhe , Deng Xiaochong , Zhou Xiqian , Fang Lin 

TITLE=The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.645682

DOI=10.3389/fonc.2021.645682

ISSN=2234-943X

ABSTRACT=<p>In this study, we demonstrated that miR-640 is significantly downregulated in breast cancer (BC) tissues and cell lines. Overexpression of miR-640 inhibited the proliferation and migration of BC <italic>in vitro</italic> and <italic>in vivo</italic>, while depletion of miR-640 exhibited the opposite effect. Importantly, miR-640 could directly target Wnt7b, thereby regulating Wnt/β-catenin signaling pathway in BC. In conclusion, miR-640/Wnt7b suppresses BC cells tumorigenesis <italic>via</italic> Wnt/β-catenin signaling pathway, which might be novel targets for BC targeted therapy.</p>