AUTHOR=Cerchione Claudio , Romano Alessandra , Daver Naval , DiNardo Courtney , Jabbour Elias Joseph , Konopleva Marina , Ravandi-Kashani Farhad , Kadia Tapan , Martelli Maria Paola , Isidori Alessandro , Martinelli Giovanni , Kantarjian Hagop 

TITLE=IDH1/IDH2 Inhibition in Acute Myeloid Leukemia

JOURNAL=Frontiers in Oncology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.639387

DOI=10.3389/fonc.2021.639387

ISSN=2234-943X

ABSTRACT=In the recent years, the emerging pathogenic role of mutations in isocitrate dehydrogenases (IDH) 1 and 2, affecting approximately 20% of patients with acute myeloid leukemia (AML), lead to the development of an individualized treatment strategy. 
Targeting IDH mutations in AML is a biologically informed and rational strategy to promote clinical responses, primarily through differentiation and maturation of the malignant clone. Phase I/II trials have shown evidence of safety, tolerability, and encouraging evidence of efficacy of two small molecule inhibitors targeting IDH2 and IDH1 gene mutations, respectively enasidenib and ivosidenib. 
In this review, the contribution of IDH1/IDH2 mutations in leukemogenesis and progress of targeted therapeutics in AML will be highlighted.