Qiang Li
Daniel Staiculescu2
Yurong Zhou
Jiang Chen- 1Department of Radiology, The Affiliated People’s Hospital of Ningbo University, Ningbo, China
- 2Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- 3Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China
- 4Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
Pancreatic leiomyosarcoma (PL) is a very rare, malignant neoplasm with a very poor prognosis. Here, we examine a novel case of PL with schistosomiasis hematobia. The patient had been initially misdiagnosed by the first magnetic resonance imaging (MRI). The second imaging examination demonstrated an enlarged heterogeneous tumor mass in the body-tail of pancreas. Following image analysis, the patient underwent a pancreatectomy, splenectomy and lymph node dissections. Sixteen months after the tumor resection, follow-up computed tomography (CT) and MRI revealed tumor metastasis in the liver and lung. PL has non-specific clinical manifestations and imaging characteristics, making early diagnosis very challenging. When it is difficult to distinguish between benign and malignant pancreatic lesions, short-term imaging follow-up is preferred. In this case report, we discuss the relationship between PL and schistosomiasis hematobia.
Introduction
Pancreatic leiomyosarcoma (PL) is a very rare, malignant neoplasm occurring in the pancreas, accounting for 0.1% of tumors primarily arising from pancreas (1–3). It is thought to arise from nearby the pancreatic duct or pancreatic blood vessels (4). The prognosis of pancreatic leiomyosarcoma is very poor, with a 5-year mortality rate of 77.8% (4–6). Here, we report a case of PL with schistosomiasis hematobia.
Case Presentation
A geriatric female, of over 70 years, presented epigastric pain in April 2013. The patient underwent MRI, which revealed abnormal signal changes in the body of pancreas, the atrophy of the pancreatic tail, dilation of distal pancreatic duct, and less enhancement than the pancreatic parenchyma (Figure 1). It is difficult to tell if the pancreatic lesions are benign, premalignant, or malignant through this imaging alone. Thus, an imaging follow-up was recommended. In November 2014, the ultrasound imaging follow-up showed a significantly enlarged mass, which was confirmed by computed tomography (CT) and MRI examination. CT also revealed a tumor mass in the body-tail of pancreas, demonstrating that the mass contains mixed cyst-like and solid components as well as peripheral patchy calcification on plain CT. Mild enhancement of the solid components and non-enhancement of the central necrosis were also present (Figures 2A, B). MRI showed inhomogeneous hyperintensity on T2 weighted images, restricted diffusion on diffusion-weighted images, and mild inhomogeneous enhancement of the solid components on the gadolinium-enhanced T1 weighted images (Figures 2C–H). Laboratory testing showed increased serum ferritin (280.90 ng/ml), while other tumor markers (such as alpha-fetoprotein (α-AFP), carcino-embryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and carbohydrate antigen 125 (CA-125)) were normal. Since no metastases were found, a pancreatic tumor resection was performed. A 5 × 5 cm tumor mass was found in the body-tail of the pancreas with enlarged lymph nodes, surrounding the hepatic artery, in the laparotomy. Adjacent to the pancreatic tumor mass, another 2 × 2 cm tumor was found adhering to the splenetic vein. After the tumor resectability was thoroughly assessed, the patient underwent a pancreatectomy with a splenectomy and regional lymph node dissection. Histological analysis showed that the mass located in the pancreatic body and tail had focal necrosis. The diagnosis of PL was confirmed by H&E morphology and immunohistochemical staining (Figure 3A). Interestingly, few dead Schistosoma eggs were found in the tumor tissues (Figure 3B), and a large number of eosinophils surrounded the Schistosoma eggs. Twenty months after surgery the patient developed liver and lung metastasis (Figure 4), and she died three months later.
Figure 1 The first abdominal MRI. Both MR T1 (A) and T2 weighted image (B) showed the atrophy of the pancreas and inhomogeneous signal change in the body and tail of the pancreas. Diffusion weighted image didn’t show the apparent tumor mass-related signal change (C). Gadolinium-enhanced T1 weighted images including early arterial phase (D), late arterial phase (E) and portal phase images (F), depicted multiple irregular hypointense signals without demonstrating a typical tumor imaging characteristics, which was regarded as an indeterminate lesion in the pancreas. A recommendation of imaging follow-up was made for the patient.
Figure 2 The second imaging. CT without contrast administration show the significantly enlarged tumor mass with heterogeneous components of central cystic low attenuation, peripheral solid isointensity and small patchy calcification (A, arrow). Contrast-enhanced CT shows the tumor mass with intermediate enhancement of the peripheral component and the non-enhanced cyst-like central area (B, arrow). MR T2 (C) and T2 weighted images (D) show heterogeneous hyper-signal intensity and hypo-signal intensity in the central area of the tumor (arrow). DWI shows the apparent diffusion restriction-induced heterogeneous hypersignal intensity (E, arrow). Contrast-enhanced MR weighted images of arterial (F), portal (G) and equilibrium phase (H) show the tumor mass with intermediate enhancement of the peripheral component, the non-enhanced cyst-like central area (arrows).
Figure 3 Pathological examination. Histology with H&E staining of the excised pancreatic tumor mass shows large pleomorphic, spindle-shaped cells, fibrosis, which indicate a stromal malignancy (A). Another slide of the tumor shows schistosome in the tumor tissue (B, arrow).
Figure 4 Follow-up images after surgery. Lung CT shows multiple nodules in the lung and thoracic effusion, which indicate the lung and possible pleural metastasis (A, B, arrow). MR T1 weighted images show a well-demarcated, heterogeneous hypointense signal tumor in the right lobe of the liver with patchy hypersignal intensities in the central of the tumor (C, arrow). MR weighted images show the tumor mass with heterogeneous hypersignal intensities (D, arrow). Contrast-enhanced MR weighted images of arterial (E), portal phase (F) show the tumor mass with intermediate enhancement of the peripheral component, the non-enhanced hypointense signal central area (arrows).
Discussion
PL is a rare malignant neoplasm, first reported by Ross in 1951 (2). Fewer than 100 cases of PL have been documented in the literature (7). The mean age of patients is 53.9 ± 14.7 years old (range = 14–87 years) with an equal incidence rate between men and women (3, 7). The most common symptoms of PL include abdominal pain, weight loss, epigastric tenderness, and abdominal mass formation (8, 9). The size of the tumors is quite variable (from 3 to 25 cm) with median size of 10.5 cm (4, 10). Patients that present large tumors also display hemorrhagic, necrotic changes, which are usually associated with a highly aggressive behavior and can be misdiagnosed as a pseudocyst or cystadenocarcinom in early stage by imaging. The only potentially curative approach is surgery before widespread metastasis.
What were the imaging features of PL with Schistosoma japonicum, and why it was misdiagnosed by first MRI? PL is characterized by a large heterogeneous mass with peripheral enhancement via CT scanning while MRI scanning shows hyperintensity of a mass on T2 weighted images with peripheral enhancement (7, 11, 12). In the above case, the main imaging characteristic was a heterogeneous mass with a cystic component due to necrosis at pancreatic body and tail. These image signs were similar when compared with previous PL reports, but many of these same features can also be found in pancreatic pseudocysts (13, 14), mucinous cystic neoplasms (13, 15), intraductal papillary mucinous tumor(IPMT) (16), solid and papillary epithelial neoplasm (SPEN) (17, 18), and pancreatic neuroendocrine tumors (19). Since there are no specific imaging features unique to just PL and the substantial overlap of the population and symptoms compared with other pancreas malignant tumors, an accurate differential diagnosis is difficult to obtain. A cystic lesion of the pancreas, on first MRI, was misdiagnosed in the above case without further examination, such as a PET/CT or biopsy.
Was PL induced by S. japonicum or was primary malignant tumor accompanied with parasitic infection? The host–parasite interactions during schistosomiasis induce a Th1/Th2 response by a subset of immune response genes, such as IL-4, IL-6, and IL-10) (20). S. japonicum is a chronic infection where regulatory pathways accommodate host permissiveness to schistosome establishment of productive parasitism (20, 21). Associated carcinogenesis might be induced, by frequent reinfections, due to increased proliferation, angiogenesis, mutagenesis, and oncogene activation (22, 23). While Schistosomiasis-associated malignant tumors might also be induced by activated macrophages and leukocytes, many mechanisms remain unclear (1, 22, 24). There were a few scattered neutrophils surrounding Schistosoma eggs without microphages in our presented case, so schistosomiasis may increase PL progression.
In summary, PL has non-specific clinical manifestations and imaging characteristics, but shares similar imaging appearance with many other pancreatic neoplasms. When it is difficult to distinguish between benign and malignant pancreatic lesions, other examinations (such as PET/CT, biopsy) and short-term imaging follow-up are preferred. The relationship between schistosomiasis and PL might be not relevant, but more clinical evidence is needed to confirm this assertion.
Data Availability Statement
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
Ethics Statement
Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.
Author Contributions
QL and YZ took the lead in drafting the manuscript and provided magnetic resonance images and H&E staining. DS, YZ, and JC provided supervision and participated in the literature review and in drafting the manuscript. All authors contributed to the article and approved the submitted version.
Funding
This work was supported by Public Welfare Technology Research Program of Zhejiang Natural Science Foundation (grant number: LGF20H180005 to QL), China Postdoctoral Science Foundation Funded Project (grant number: 2020T130584 to JC), and China Scholarship Council (grant number: 201806325017, to JC). This work was also supported by Wuhan University Training Program for Young Talents Abroad (grant number 2018-105 to YZ).
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Acknowledgments
We thank the patient who participated in the study for providing data.
Abbreviations
PL, Pancreatic leiomyosarcoma; MRI, magnetic resonance imaging; CT, computed tomography; α-AFP, alpha-fetoprotein; CEA, carcino-embryonic antigen; CA19-9, carbohydrate antigen 19-9; CA-125, carbohydrate antigen 125; IPMT, Intraductal papillary mucinous tumor; SPEN, solid and papillary epithelial neoplasm.
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Keywords: schistosomiasis hematobia, imaging, metastasis, differential diagnosis, pancreatic leiomyosarcoma
Citation: Li Q, Staiculescu D, Zhou Y and Chen J (2021) Pancreatic Leiomyosarcoma With Schistosomiasis Hematobia: A Case Report and Literature Review. Front. Oncol. 11:638905. doi: 10.3389/fonc.2021.638905
Received: 07 December 2020; Accepted: 26 February 2021;
Published: 31 March 2021.
Edited by:
Emanuele Neri, University of Pisa, ItalyReviewed by:
Cosimo Sperti, University of Padua, ItalyPiero Boraschi, Pisa University Hospital, Italy
Copyright © 2021 Li, Staiculescu, Zhou and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jiang Chen, chenjiang520@zju.edu.cn; Yurong Zhou, fiedmouse@163.com