AUTHOR=Kim Isaac , Rajamanickam Venkatesh , Bernard Brady , Chun Brie , Wu Yaping , Martel Maritza , Sun Zhaoyu , Redmond William L. , Sanchez Katherine , Basho Reva , McArthur Heather , Page David B. TITLE=A Case Series of Metastatic Metaplastic Breast Carcinoma Treated With Anti-PD-1 Therapy JOURNAL=Frontiers in Oncology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.635237 DOI=10.3389/fonc.2021.635237 ISSN=2234-943X ABSTRACT=

Metaplastic breast cancer is a rare and often chemo-refractory subtype of breast cancer with poor prognosis and limited treatment options. Recent studies have reported overexpression of programmed death ligand 1 (PD-L1) in metaplastic breast cancers, and there are several reports of anti-PD-1/L1 being potentially active in this disease. In this case series, we present 5 patients with metastatic metaplastic breast cancer treated with anti-PD-1-based therapy at a single center, with 3 of 5 cases demonstrating a response to therapy, and one of the responding cases being a metaplastic lobular carcinoma with low-level hormone receptor expression. Cases were evaluated for PD-L1 expression, tumor infiltrating lymphocytes (TILs), DNA mutations, RNA sequencing, and T-cell receptor sequencing. Duration of the response in these cases was limited, in contrast to the more durable responses noted in other recently published reports.