AUTHOR=Tartarone Alfredo , Lapadula Vittoria , Di Micco Concetta , Rossi Gemma , Ottanelli Carlotta , Marini Andrea , Giorgione Roberta , Ferrari Katia , Catalano Martina , Voltolini Luca , Mini Enrico , Roviello Giandomenico 

TITLE=Beyond Conventional: The New Horizon of Targeted Therapy for the Treatment of Advanced Non Small Cell Lung Cancer

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.632256

DOI=10.3389/fonc.2021.632256

ISSN=2234-943X

ABSTRACT=<p>In the last few years the advent of targeted therapies against oncogenic drivers significantly improved the survival of non small cell lung cancer (NSCLC) patients with a favourable toxicity profile. Therefore, genetic testing, including at least EGFR mutations and ALK/ROS1 rearrangements, should be performed in all NSCLC patients (in particular with adenocarcinoma) who received a diagnosis of advanced disease. This review focuses on novel druggable oncogenic drivers, such as MET exon 14 mutations/MET amplification, RET fusions, BRAF V600E mutations, KRAS G12C mutations, NTRK rearrangements, and HER2 alterations.</p>