AUTHOR=Kunos Charles A. , Howells Rodney , Chauhan Aman , Myint Zin W. , Bernard Mark E. , El Khouli Riham , Capala Jacek TITLE=Radiopharmaceutical Validation for Clinical Use JOURNAL=Frontiers in Oncology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.630827 DOI=10.3389/fonc.2021.630827 ISSN=2234-943X ABSTRACT=
Radiopharmaceuticals are reemerging as attractive anticancer agents, but there are no universally adopted guidelines or standardized procedures for evaluating agent validity before early-phase trial implementation. To validate a radiopharmaceutical, it is desirous for the radiopharmaceutical to be specific, selective, and deliverable against tumors of a given, molecularly defined cancer for which it is intended to treat. In this article, we discuss four levels of evidence—target antigen immunohistochemistry,