AUTHOR=Zhao Guang-Yin , Ning Zhao-Feng , Wang Rui 

TITLE=RETRACTED: LncRNA SNHG19 Promotes the Development of Non-Small Cell Lung Cancer via Mediating miR-137/E2F7 Axis

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.630241

DOI=10.3389/fonc.2021.630241

ISSN=2234-943X

ABSTRACT=<sec><title>Objective</title><p>Non-small cell lung cancer (NSCLC) is a common malignant tumor, which has high incidence and low the 5-year survival rate. Long non-coding RNAs (lncRNAs) play critical roles in carcinoma occurrence and metastasis. Herein, our aim was to investigate the effects of lncRNA SNHG19 in NSCLC progression.</p></sec><sec><title>Materials and Methods</title><p>Long non-coding RNA Small Nucleolar RNA Host Gene 19 (lncRNA SNHG19) expression level was measured by bioinformatics and qRT-PCR. Edu, Transwell, and scratch assays were performed to explore the role of si-SNHG19 or SNHG19 on NSCLC progression. Luciferase assay was used to verify the relationship between SNHG19/E2F7 and miR-137. The experiment of Xenograft was used for exploring the function of SNHG19 <italic>in vivo</italic>.</p></sec><sec><title>Results</title><p>SNHG19 was upregulated in cancer tissues, patients plasma and cell lines of NSCLC. Knockdown of SNHG19 inhibited cell proliferation, migration, and invasion. Luciferase assay confirmed that SNHG19 regulated E2F7 expression <italic>via</italic> interacting with miR-137. Overexpression of SNHG19 accelerated NSCLC tumor progression <italic>via</italic> miR-137/E2F7 axis both <italic>in vitro</italic> and <italic>in vivo</italic>.</p></sec><sec><title>Conclusions</title><p>Our results clarified the SNHG19 function for the first time, and SNHG19 promoted the progression of NSCLC, which was mediated by the miR-137/E2F7 axis. This study might provide new understanding and targets for NSCLC diagnosis and treatment.</p></sec>